Renal tubular cell binding of β‐catenin to TCF1 versus FoxO1 is associated with chronic interstitial fibrosis in transplanted kidneys

β‐Catenin is an important co‐factor which binds multiple transcriptional molecules and mediates fibrogenic signaling pathways. Its role in kidney transplantation is unknown. We quantified binding of β‐catenin within renal tubular epithelial cells to transcription factors, TCF1 and FoxO1, using a proximity ligation assay in 240 transplanted kidneys, and evaluated their pathological and clinical outcomes. β‐Catenin/FoxO1 binding in 1‐month protocol biopsies inversely correlated with contemporaneous chronic fibrosis, subsequent inflammation. and inflammatory fibrosis (P