Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition

Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition

This review focuses on an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cy...

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Veröffentlicht in:Cleveland Clinic journal of medicine 2021-03
Hauptverfasser: Calabrese, Leonard H, Lenfant, Tiphaine, Calabrese, Cassandra
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:This review focuses on an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
ISSN:0891-1150
1939-2869
DOI:10.3949/ccjm.87a.ccc060