Responses to intra-luteal administration of cloprostenol in dairy cows

The aim of the study was to determine the luteolytic dose of cloprostenol administered directly into the corpus luteum (CL; intra-luteal treatment, ILT) in dairy cattle. Cows of two control groups were treated with 500 μg of cloprostenol (Estrumate®) intramuscularly (IM-500) or via ILT with 0.2 mL o...

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Veröffentlicht in:Animal reproduction science 2020-08, Vol.219, p.106512-106512, Article 106512
Hauptverfasser: Andrlikova, M., Andrlova, P., Barbato, O., Tabery, J., Bina, V., Vostry, L., Cech, S.
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Sprache:eng
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Zusammenfassung:The aim of the study was to determine the luteolytic dose of cloprostenol administered directly into the corpus luteum (CL; intra-luteal treatment, ILT) in dairy cattle. Cows of two control groups were treated with 500 μg of cloprostenol (Estrumate®) intramuscularly (IM-500) or via ILT with 0.2 mL of physiological solution (ILT-0). Cows of four experimental groups were treated by ILT with cloprostenol in doses 5, 25, 50 and 100 μg (ILT-5, -25, -50 and -100 groups). Progesterone concentrations (P4) and size of CL were evaluated to assess luteolysis at 0, 0.5, 1, 2, 4, 8, 24 and 48 h or at 0, 24 and 48 h after ILT, respectively. Cows in the ILT-0 and -5 groups were unaffected by ILT. The P4 concentrations were less in cows of the IM-500, as well as ILT-25, -50 and -100 groups at 48 h subsequent to ILT. The size of the CL was less in cows of IM-500, as well as ILT-25, -50 and -100 groups at 48 h after ILT. There were P4 concentrations of about 1 ng/mL 48 h after ILT in cows of the IM-500, as well as ILT-50 and -100 groups. In conclusion, the cloprostenol dose of 50 μg administered intra-luteally is a luteolytic dose in cows.
ISSN:0378-4320
1873-2232
DOI:10.1016/j.anireprosci.2020.106512