Differences in 7th and 8th edition American Joint Committee on Cancer staging for periocular sebaceous carcinoma

To examine the clinicopathological features of periocular sebaceous carcinoma and describe the differences in T category between the seventh and eighth editions of the American Joint Committee on Cancer (AJCC) staging system for eyelid carcinoma in a Canadian population. This study is a single-centre retrospective review of consecutive patients diagnosed with periocular sebaceous carcinoma at Vancouver General Hospital over a 24-year period. Medical records and pathological slides were reviewed. Clinicopathological features, management, and outcomes were recorded. Each carcinoma was staged as per both the seventh and eighth editions AJCC staging system for eyelid carcinoma. Forty-five patients (25 women, 20 men) were identified with a median age of 74 years (range 42–91 years). Tumour size was with a median of 4 mm (range 1–30 mm) and a mean of 6.7 mm. Using the seventh edition, patients were assigned the following T categories: Tis = 10, T1 = 9, T2 = 11, T3 = 8, T4 = 0. Under the eighth edition, 18 of 45 patients (40%) were restaged, with the majority of these (15 patients, 33%) being downstaged. The eighth edition categories were as follows: Tis = 10, T1 = 22, T2 = 3, T3 = 0, T4 = 3. Three patients developed disease recurrence, 2 of whom (staged T2c and T4b) died of disease. There were substantial differences in the seventh and eighth editions of AJCC for the staging of periocular sebaceous carcinoma. Our series had small tumours at presentation with infrequent recurrences or metastases. We found a high number of patients with in-situ-only disease. Examiner les caractéristiques clinicopathologiques du carcinome sébacé périoculaire et décrire les différences en matière de classification de la tumeur (T) entre la 7e et la 8e édition du système de détermination des stades de l’American Joint Committee on Cancer (AJCC) dans le carcinome de la paupière au sein d'une population canadienne. Cette étude rétrospective réalisée dans un seul centre porte sur des patients consécutifs qui ont reçu un diagnostic de carcinome sébacé périoculaire au Vancouver General Hospital sur une période de 24 ans. Ont été passés en revue les dossiers médicaux et les lames anatomopathologiques. Les caractéristiques clinicopathologiques, la prise en charge et les résultats ont été notés. Le stade de chaque carcinome a été établi conformément aux 2 éditions du système de détermination des stades de l'AJCC pour le carcinome de la paupière. Quelque 45 patients (25 femmes et 20 hommes) d