2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma
Purpose To explore the potential parameters from preoperative 2-[ 18 F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC). Methods One hundred twenty-five patients with newly...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-02, Vol.48 (2), p.570-579 |
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| creator | Zhao, Yanyan Wu, Caixia Li, Wei Chen, Xueqi Li, Ziao Liao, Xuhe Cui, Yonggang Zhao, Guangyu Liu, Meng Fu, Zhanli |
| description | Purpose
To explore the potential parameters from preoperative 2-[
18
F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC).
Methods
One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[
18
F]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[
18
F]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade.
Results
Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (
P
= 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (
P
|
| doi_str_mv | 10.1007/s00259-020-04996-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2435755556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2480546034</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-34dbb00fbf0771158e50caae6713d2853c823d2a0959444d09408eca57e1ab333</originalsourceid><addsrcrecordid>eNp9kF1rFDEUhoNYbG39A15IwBtvxj35miSXsnbbQqGFbvFCNJzJnK1T5mObzCL-e2edWsGL5iYv5DlvDg9jbwV8FAB2kQGk8QVIKEB7Xxb6BTsSpfCFBedfPmULh-x1zvcAwknnX7FDJZ3Q3voj9l0WX4VbfVt9PuPXp-vFcs23mLCjkVLmmPMQGxyp5j-b8Qf_cn61uLi5veZ3CWviTc9jS5h4pLbliXps5xgxxaYfOjxhBxtsM715vI_Z7ep0vTwvLq_OLpafLouopR4LpeuqAthUG7BWCOPIQESk0gpVS2dUdHIKCN54rXUNXoOjiMaSwEopdcw-zL3bNDzsKI-ha_J-Fexp2OUgtTLWTKec0Pf_offDLk2r7ykHRpeg9ETJmYppyDnRJmxT02H6FQSEvf0w2w-T_fDHftgPvXus3lUd1U8jf3VPgJqBPD31d5T-_f1M7W8-eYwI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2480546034</pqid></control><display><type>article</type><title>2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma</title><source>SpringerLink (Online service)</source><creator>Zhao, Yanyan ; Wu, Caixia ; Li, Wei ; Chen, Xueqi ; Li, Ziao ; Liao, Xuhe ; Cui, Yonggang ; Zhao, Guangyu ; Liu, Meng ; Fu, Zhanli</creator><creatorcontrib>Zhao, Yanyan ; Wu, Caixia ; Li, Wei ; Chen, Xueqi ; Li, Ziao ; Liao, Xuhe ; Cui, Yonggang ; Zhao, Guangyu ; Liu, Meng ; Fu, Zhanli</creatorcontrib><description>Purpose
To explore the potential parameters from preoperative 2-[
18
F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC).
Methods
One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[
18
F]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[
18
F]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade.
Results
Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (
P
= 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (
P
< 0.05). In multivariate analysis, TLR (
P
< 0.001; OR: 1.732; 95%CI: 1.289–2.328) and tumor thrombus (
P
< 0.001; OR: 6.199; 95%CI: 2.499–15.375) were significant factors for differentiating WHO/ISUP grades.
Conclusion
Elevated TLR (> 1.63) and presence of tumor thrombus from preoperative 2-[
18
F]FDG PET/CT can distinguish high WHO/ISUP grade ccRCC effectively. 2-[
18
F]FDG PET/CT may be a feasible method for noninvasive assessment of WHO/ISUP grade.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-020-04996-4</identifier><identifier>PMID: 32814979</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Blood clots ; Cardiology ; Clear cell-type renal cell carcinoma ; Computed tomography ; Fluorine isotopes ; Imaging ; Kidney cancer ; Medicine ; Medicine & Public Health ; Metabolism ; Metastases ; Multivariate analysis ; Nuclear Medicine ; Oncology ; Oncology – Genitourinary ; Original Article ; Orthopedics ; Parameter identification ; Positron emission ; Positron emission tomography ; Radiology ; Regression analysis ; Surgery ; Thrombosis ; Tomography ; Tumors</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-02, Vol.48 (2), p.570-579</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-34dbb00fbf0771158e50caae6713d2853c823d2a0959444d09408eca57e1ab333</citedby><cites>FETCH-LOGICAL-c424t-34dbb00fbf0771158e50caae6713d2853c823d2a0959444d09408eca57e1ab333</cites><orcidid>0000-0002-6960-3163</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-020-04996-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-020-04996-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32814979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Yanyan</creatorcontrib><creatorcontrib>Wu, Caixia</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Chen, Xueqi</creatorcontrib><creatorcontrib>Li, Ziao</creatorcontrib><creatorcontrib>Liao, Xuhe</creatorcontrib><creatorcontrib>Cui, Yonggang</creatorcontrib><creatorcontrib>Zhao, Guangyu</creatorcontrib><creatorcontrib>Liu, Meng</creatorcontrib><creatorcontrib>Fu, Zhanli</creatorcontrib><title>2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To explore the potential parameters from preoperative 2-[
18
F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC).
Methods
One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[
18
F]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[
18
F]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade.
Results
Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (
P
= 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (
P
< 0.05). In multivariate analysis, TLR (
P
< 0.001; OR: 1.732; 95%CI: 1.289–2.328) and tumor thrombus (
P
< 0.001; OR: 6.199; 95%CI: 2.499–15.375) were significant factors for differentiating WHO/ISUP grades.
Conclusion
Elevated TLR (> 1.63) and presence of tumor thrombus from preoperative 2-[
18
F]FDG PET/CT can distinguish high WHO/ISUP grade ccRCC effectively. 2-[
18
F]FDG PET/CT may be a feasible method for noninvasive assessment of WHO/ISUP grade.</description><subject>Biopsy</subject><subject>Blood clots</subject><subject>Cardiology</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Computed tomography</subject><subject>Fluorine isotopes</subject><subject>Imaging</subject><subject>Kidney cancer</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Oncology – Genitourinary</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Parameter identification</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>Thrombosis</subject><subject>Tomography</subject><subject>Tumors</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kF1rFDEUhoNYbG39A15IwBtvxj35miSXsnbbQqGFbvFCNJzJnK1T5mObzCL-e2edWsGL5iYv5DlvDg9jbwV8FAB2kQGk8QVIKEB7Xxb6BTsSpfCFBedfPmULh-x1zvcAwknnX7FDJZ3Q3voj9l0WX4VbfVt9PuPXp-vFcs23mLCjkVLmmPMQGxyp5j-b8Qf_cn61uLi5veZ3CWviTc9jS5h4pLbliXps5xgxxaYfOjxhBxtsM715vI_Z7ep0vTwvLq_OLpafLouopR4LpeuqAthUG7BWCOPIQESk0gpVS2dUdHIKCN54rXUNXoOjiMaSwEopdcw-zL3bNDzsKI-ha_J-Fexp2OUgtTLWTKec0Pf_offDLk2r7ykHRpeg9ETJmYppyDnRJmxT02H6FQSEvf0w2w-T_fDHftgPvXus3lUd1U8jf3VPgJqBPD31d5T-_f1M7W8-eYwI</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Zhao, Yanyan</creator><creator>Wu, Caixia</creator><creator>Li, Wei</creator><creator>Chen, Xueqi</creator><creator>Li, Ziao</creator><creator>Liao, Xuhe</creator><creator>Cui, Yonggang</creator><creator>Zhao, Guangyu</creator><creator>Liu, Meng</creator><creator>Fu, Zhanli</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6960-3163</orcidid></search><sort><creationdate>20210201</creationdate><title>2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma</title><author>Zhao, Yanyan ; Wu, Caixia ; Li, Wei ; Chen, Xueqi ; Li, Ziao ; Liao, Xuhe ; Cui, Yonggang ; Zhao, Guangyu ; Liu, Meng ; Fu, Zhanli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-34dbb00fbf0771158e50caae6713d2853c823d2a0959444d09408eca57e1ab333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biopsy</topic><topic>Blood clots</topic><topic>Cardiology</topic><topic>Clear cell-type renal cell carcinoma</topic><topic>Computed tomography</topic><topic>Fluorine isotopes</topic><topic>Imaging</topic><topic>Kidney cancer</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Oncology – Genitourinary</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Parameter identification</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>Thrombosis</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yanyan</creatorcontrib><creatorcontrib>Wu, Caixia</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Chen, Xueqi</creatorcontrib><creatorcontrib>Li, Ziao</creatorcontrib><creatorcontrib>Liao, Xuhe</creatorcontrib><creatorcontrib>Cui, Yonggang</creatorcontrib><creatorcontrib>Zhao, Guangyu</creatorcontrib><creatorcontrib>Liu, Meng</creatorcontrib><creatorcontrib>Fu, Zhanli</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yanyan</au><au>Wu, Caixia</au><au>Li, Wei</au><au>Chen, Xueqi</au><au>Li, Ziao</au><au>Liao, Xuhe</au><au>Cui, Yonggang</au><au>Zhao, Guangyu</au><au>Liu, Meng</au><au>Fu, Zhanli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>48</volume><issue>2</issue><spage>570</spage><epage>579</epage><pages>570-579</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To explore the potential parameters from preoperative 2-[
18
F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC).
Methods
One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[
18
F]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[
18
F]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade.
Results
Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (
P
= 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (
P
< 0.05). In multivariate analysis, TLR (
P
< 0.001; OR: 1.732; 95%CI: 1.289–2.328) and tumor thrombus (
P
< 0.001; OR: 6.199; 95%CI: 2.499–15.375) were significant factors for differentiating WHO/ISUP grades.
Conclusion
Elevated TLR (> 1.63) and presence of tumor thrombus from preoperative 2-[
18
F]FDG PET/CT can distinguish high WHO/ISUP grade ccRCC effectively. 2-[
18
F]FDG PET/CT may be a feasible method for noninvasive assessment of WHO/ISUP grade.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32814979</pmid><doi>10.1007/s00259-020-04996-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6960-3163</orcidid></addata></record> |
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| source | SpringerLink (Online service) |
| subjects | Biopsy Blood clots Cardiology Clear cell-type renal cell carcinoma Computed tomography Fluorine isotopes Imaging Kidney cancer Medicine Medicine & Public Health Metabolism Metastases Multivariate analysis Nuclear Medicine Oncology Oncology – Genitourinary Original Article Orthopedics Parameter identification Positron emission Positron emission tomography Radiology Regression analysis Surgery Thrombosis Tomography Tumors |
| title | 2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma |
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