Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery
Background Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety. Methods Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a...
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| Veröffentlicht in: | World journal of surgery 2020-12, Vol.44 (12), p.4214-4220 |
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| creator | Okubo, Satoshi Shindoh, Junichi Kobayashi, Yuta Hashimoto, Masaji |
| description | Background
Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety.
Methods
Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a sheet-type adhesion barrier (Interceed
®
) and 134 patients who did not receive any adhesion barriers during hepatectomy. Propensity score (PS) adjustment was used to account for potential bias to receive Interceed.
Results
In the PS-adjusted population, the incidences of both global postoperative morbidities and major abdominal morbidities showed no significant difference between the Interceed group and the control group (17.9% vs. 17.6%;
P
= 0.948 and 7.8% vs. 9.1%;
P
= 0.813, respectively). Multivariate analysis showed that age + 10 years (odds ratio [OR], 1.70; 95% CI, 1.15–2.50;
P
= 0.007), estimated blood loss + 100 mL (OR, 1.05; 95% CI, 1.01–1.09,
P
= 0.009), and laparoscopic approach (OR, 0.10; 95% CI, 0.01–0.75;
P
= 0.026) were independent predictors for global postoperative morbidities and operation time + 1 h (OR, 1.56; 95% CI, 1.23–1.96;
P
|
| doi_str_mv | 10.1007/s00268-020-05743-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2435189857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2435189857</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4929-bd390c48361b376ce9a0edd6661dfdd8c13593c8a42aa5bd899ca5516317d7593</originalsourceid><addsrcrecordid>eNqNkMtO3DAUhq2qFQyXF2CBInUDi7THl9gOO-4XjYTQgLq0PPYJBM0kU3tSlJfiIfpk9RBoJRYVq2Pp_87R74-QHQrfKID6HgGY1DkwyKFQgufiExlRwVnOOOOfyQi4FOlN-TrZiPERgCoJco2sc6ZBgypG5GZiK1z2WVtldxFXw2aTB8RlftsvMDv0DxjrtsmObAg1hmzvsllicIj-9_N-dtKFurnPxvWvFE26cI-h3yJfKjuLuP06N8nd2ent8UU-vj6_PD4c506UrMynnpfghOaSTrmSDksL6L2UkvrKe-0oL0rutBXM2mLqdVk6WxRUcqq8StEm2RvuLkL7s8O4NPM6OpzNbINtFw0TvKC61IVK6Nd36GPbhSa1S5SiyZ3iK4oNlAttjAErswj13IbeUDAr4WYQbpJw8yLciLS0-3q6m87R_115M5yAgwF4qmfYf-Ck-XE1OTpL2csf-bAcFyvRGP4V_0-nP6htmnw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471574737</pqid></control><display><type>article</type><title>Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery</title><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals - AutoHoldings</source><creator>Okubo, Satoshi ; Shindoh, Junichi ; Kobayashi, Yuta ; Hashimoto, Masaji</creator><creatorcontrib>Okubo, Satoshi ; Shindoh, Junichi ; Kobayashi, Yuta ; Hashimoto, Masaji</creatorcontrib><description>Background
Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety.
Methods
Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a sheet-type adhesion barrier (Interceed
®
) and 134 patients who did not receive any adhesion barriers during hepatectomy. Propensity score (PS) adjustment was used to account for potential bias to receive Interceed.
Results
In the PS-adjusted population, the incidences of both global postoperative morbidities and major abdominal morbidities showed no significant difference between the Interceed group and the control group (17.9% vs. 17.6%;
P
= 0.948 and 7.8% vs. 9.1%;
P
= 0.813, respectively). Multivariate analysis showed that age + 10 years (odds ratio [OR], 1.70; 95% CI, 1.15–2.50;
P
= 0.007), estimated blood loss + 100 mL (OR, 1.05; 95% CI, 1.01–1.09,
P
= 0.009), and laparoscopic approach (OR, 0.10; 95% CI, 0.01–0.75;
P
= 0.026) were independent predictors for global postoperative morbidities and operation time + 1 h (OR, 1.56; 95% CI, 1.23–1.96;
P
< 0.001) was a risk factor for major abdominal morbidity, while no specific association between the use of Interceed and the risk of postoperative morbidity was observed.
Conclusions
Use of Interceed does not increase the risk of postoperative morbidities after hepatectomy.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-020-05743-4</identifier><identifier>PMID: 32808075</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdomen ; Abdominal Surgery ; Adhesion ; Cardiac Surgery ; General Surgery ; Hepatectomy ; Laparoscopy ; Medicine ; Medicine & Public Health ; Morbidity ; Multivariate analysis ; Original Scientific Report ; Risk analysis ; Risk factors ; Safety ; Surgery ; Thoracic Surgery ; Vascular Surgery</subject><ispartof>World journal of surgery, 2020-12, Vol.44 (12), p.4214-4220</ispartof><rights>Société Internationale de Chirurgie 2020</rights><rights>2020 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>Société Internationale de Chirurgie 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4929-bd390c48361b376ce9a0edd6661dfdd8c13593c8a42aa5bd899ca5516317d7593</citedby><cites>FETCH-LOGICAL-c4929-bd390c48361b376ce9a0edd6661dfdd8c13593c8a42aa5bd899ca5516317d7593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-020-05743-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-020-05743-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,41467,42536,45553,45554,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32808075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okubo, Satoshi</creatorcontrib><creatorcontrib>Shindoh, Junichi</creatorcontrib><creatorcontrib>Kobayashi, Yuta</creatorcontrib><creatorcontrib>Hashimoto, Masaji</creatorcontrib><title>Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety.
Methods
Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a sheet-type adhesion barrier (Interceed
®
) and 134 patients who did not receive any adhesion barriers during hepatectomy. Propensity score (PS) adjustment was used to account for potential bias to receive Interceed.
Results
In the PS-adjusted population, the incidences of both global postoperative morbidities and major abdominal morbidities showed no significant difference between the Interceed group and the control group (17.9% vs. 17.6%;
P
= 0.948 and 7.8% vs. 9.1%;
P
= 0.813, respectively). Multivariate analysis showed that age + 10 years (odds ratio [OR], 1.70; 95% CI, 1.15–2.50;
P
= 0.007), estimated blood loss + 100 mL (OR, 1.05; 95% CI, 1.01–1.09,
P
= 0.009), and laparoscopic approach (OR, 0.10; 95% CI, 0.01–0.75;
P
= 0.026) were independent predictors for global postoperative morbidities and operation time + 1 h (OR, 1.56; 95% CI, 1.23–1.96;
P
< 0.001) was a risk factor for major abdominal morbidity, while no specific association between the use of Interceed and the risk of postoperative morbidity was observed.
Conclusions
Use of Interceed does not increase the risk of postoperative morbidities after hepatectomy.</description><subject>Abdomen</subject><subject>Abdominal Surgery</subject><subject>Adhesion</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Hepatectomy</subject><subject>Laparoscopy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Multivariate analysis</subject><subject>Original Scientific Report</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Safety</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkMtO3DAUhq2qFQyXF2CBInUDi7THl9gOO-4XjYTQgLq0PPYJBM0kU3tSlJfiIfpk9RBoJRYVq2Pp_87R74-QHQrfKID6HgGY1DkwyKFQgufiExlRwVnOOOOfyQi4FOlN-TrZiPERgCoJco2sc6ZBgypG5GZiK1z2WVtldxFXw2aTB8RlftsvMDv0DxjrtsmObAg1hmzvsllicIj-9_N-dtKFurnPxvWvFE26cI-h3yJfKjuLuP06N8nd2ent8UU-vj6_PD4c506UrMynnpfghOaSTrmSDksL6L2UkvrKe-0oL0rutBXM2mLqdVk6WxRUcqq8StEm2RvuLkL7s8O4NPM6OpzNbINtFw0TvKC61IVK6Nd36GPbhSa1S5SiyZ3iK4oNlAttjAErswj13IbeUDAr4WYQbpJw8yLciLS0-3q6m87R_115M5yAgwF4qmfYf-Ck-XE1OTpL2csf-bAcFyvRGP4V_0-nP6htmnw</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Okubo, Satoshi</creator><creator>Shindoh, Junichi</creator><creator>Kobayashi, Yuta</creator><creator>Hashimoto, Masaji</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery</title><author>Okubo, Satoshi ; Shindoh, Junichi ; Kobayashi, Yuta ; Hashimoto, Masaji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4929-bd390c48361b376ce9a0edd6661dfdd8c13593c8a42aa5bd899ca5516317d7593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Abdominal Surgery</topic><topic>Adhesion</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Hepatectomy</topic><topic>Laparoscopy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Multivariate analysis</topic><topic>Original Scientific Report</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Safety</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okubo, Satoshi</creatorcontrib><creatorcontrib>Shindoh, Junichi</creatorcontrib><creatorcontrib>Kobayashi, Yuta</creatorcontrib><creatorcontrib>Hashimoto, Masaji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okubo, Satoshi</au><au>Shindoh, Junichi</au><au>Kobayashi, Yuta</au><au>Hashimoto, Masaji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2020-12</date><risdate>2020</risdate><volume>44</volume><issue>12</issue><spage>4214</spage><epage>4220</epage><pages>4214-4220</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety.
Methods
Incidences of global postoperative morbidities and major abdominal morbidities were compared between 101 consecutive patients who received a sheet-type adhesion barrier (Interceed
®
) and 134 patients who did not receive any adhesion barriers during hepatectomy. Propensity score (PS) adjustment was used to account for potential bias to receive Interceed.
Results
In the PS-adjusted population, the incidences of both global postoperative morbidities and major abdominal morbidities showed no significant difference between the Interceed group and the control group (17.9% vs. 17.6%;
P
= 0.948 and 7.8% vs. 9.1%;
P
= 0.813, respectively). Multivariate analysis showed that age + 10 years (odds ratio [OR], 1.70; 95% CI, 1.15–2.50;
P
= 0.007), estimated blood loss + 100 mL (OR, 1.05; 95% CI, 1.01–1.09,
P
= 0.009), and laparoscopic approach (OR, 0.10; 95% CI, 0.01–0.75;
P
= 0.026) were independent predictors for global postoperative morbidities and operation time + 1 h (OR, 1.56; 95% CI, 1.23–1.96;
P
< 0.001) was a risk factor for major abdominal morbidity, while no specific association between the use of Interceed and the risk of postoperative morbidity was observed.
Conclusions
Use of Interceed does not increase the risk of postoperative morbidities after hepatectomy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32808075</pmid><doi>10.1007/s00268-020-05743-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2020-12, Vol.44 (12), p.4214-4220 |
| issn | 0364-2313 1432-2323 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2435189857 |
| source | Wiley Online Library Journals Frontfile Complete; SpringerLink Journals - AutoHoldings |
| subjects | Abdomen Abdominal Surgery Adhesion Cardiac Surgery General Surgery Hepatectomy Laparoscopy Medicine Medicine & Public Health Morbidity Multivariate analysis Original Scientific Report Risk analysis Risk factors Safety Surgery Thoracic Surgery Vascular Surgery |
| title | Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery |
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