A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer

A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer

CYP24A1 plays a role in strictly regulated vitamin D metabolism pathway and has been nominated as a prognostic biomarker for colorectal cancer (CRC). Increasing evidence suggests that circular RNAs (circRNAs) are involved in cancer initiation and progression; however, their diagnostic values in canc...

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Veröffentlicht in:Molecular biology reports 2020-09, Vol.47 (9), p.6649-6655
Hauptverfasser: Sadeghi, Hossein, Heiat, Mohammad
Format: Artikel
Sprache:eng
Schlagworte:
Animal Anatomy
Animal Biochemistry
Biomarkers
Biomedical and Life Sciences
Circular RNA
Colon cancer
Colorectal cancer
Colorectal carcinoma
Histology
Life Sciences
Morphology
Original Article
Polymerase chain reaction
Transcription
Tumor cell lines
Vitamin D
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Zusammenfassung:CYP24A1 plays a role in strictly regulated vitamin D metabolism pathway and has been nominated as a prognostic biomarker for colorectal cancer (CRC). Increasing evidence suggests that circular RNAs (circRNAs) are involved in cancer initiation and progression; however, their diagnostic values in cancers as the new potential biomarkers are still not fully understood. In the present study, by using quantitative real-time polymerase chain reaction (qRT-PCR), we demonstrated that CYP24A1 and hsa_circ_0060927 were only transcribed in 33 and 25 out of 83 CRC tissues, respectively. In these samples, we demonstrated that CYP24A1 was up-regulated in both linear and circular forms ( P  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-020-05716-9