Acute partial sleep deprivation and high-intensity interval exercise effects on postprandial endothelial function

Purpose Acute-total and chronic-partial sleep deprivation increase the risks for cardiovascular disease (CVD). Cardiovascular function assessed by flow mediated dilation (FMD) is reduced after sleep deprivation. High-intensity interval exercise (HIIE) improves postprandial FMD. Sleep-deprived individuals may practice HIIE followed by a high-fat breakfast. This study investigated the acute-partial sleep deprivation (APSD) and HIIE interaction on postprandial FMD. Methods Fifteen healthy males (age 31 ± 5 years) participated in: (a) reference sleep (~ 9.5 h) with no HIIE (RS), (b) RS and HIIE (RSX), and (c) APSD and HIIE (SSX). HIIE was performed in 3:2 min intervals at 90% and 40% of VO 2 reserve. FMD was assessed the night before (D1), the morning of the next day (D2), 1 h (1hrPE) and 4 h post HIIE (4hrPE). Results FMD% change was lower at RS compared to both RSX ( F 1,14 = 23.96, p