Carbapenem-alternative strategies for complicated urinary tract infections: A systematic review of randomized controlled trials

Carbapenem-alternative strategies for complicated urinary tract infections: A systematic review of randomized controlled trials

•Frequent use of carbapenem increases selection of carbapenem resistant Enterobacterales.•To alleviate this, we reviewed alternative strategies against complicated urinary tract infection.•In sixteen randomized controlled trials, twelve carbapenem-alternatives were investigated.•Four empirical and o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of infection 2020-10, Vol.81 (4), p.499-509
Hauptverfasser: ten Doesschate, T., van der Vaart, T.W., Damen, J.A.A., Bonten, M.J.M., van Werkhoven, C.H.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - therapeutic use
Carbapenems - therapeutic use
Humans
Intraabdominal Infections
Randomized Controlled Trials as Topic
Urinary Tract Infections - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Frequent use of carbapenem increases selection of carbapenem resistant Enterobacterales.•To alleviate this, we reviewed alternative strategies against complicated urinary tract infection.•In sixteen randomized controlled trials, twelve carbapenem-alternatives were investigated.•Four empirical and one pathogen-directed strategies are reasonable alternatives to carbapenem. Graphical abstract [Display omitted]
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2020.08.008