1H-NMR-Based salivary metabolomics from females with temporomandibular disorders – A pilot study

[Display omitted] Although temporomandibular disorder (TMD) is the second most common musculoskeletal disorder in the general population, the disease is multifactorial and presents symptoms common to other conditions which misdiagnosis can lead to treatment failure. In this case-control study, we pe...

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Veröffentlicht in:Clinica chimica acta 2020-11, Vol.510, p.625-632
Hauptverfasser: Lalue Sanches, Monique, Sforça, Maurício Luis, Guimarães Lo Turco, Edson, Faber, Jean, Smith, Ricardo Luiz, Carvalho de Moraes, Luís Otávio
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Sprache:eng
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Zusammenfassung:[Display omitted] Although temporomandibular disorder (TMD) is the second most common musculoskeletal disorder in the general population, the disease is multifactorial and presents symptoms common to other conditions which misdiagnosis can lead to treatment failure. In this case-control study, we performed, for the first time, a high-resolution 1H-nuclear magnetic resonance spectroscopy metabolomic analysis of the saliva of 26 women with TMD of muscular origin (experimental group [EG]) at the beginning (EG-pre) and at the end (EG-post) of a conservative treatment, and of 27 normal women (control group [CG]) to identify a metabolic signature for TMD. One-way analysis of variance showed changes in the concentration of phenylacetate, dimethylamine, maltose, acetoin, and isovalerate. Partial least-square discriminant analysis showed that metabolite signals did not overlap in CG X EG-pre and EG-pre X EG-post, but overlapped in CG X EG-post. The area under the receiver operating characteristic curve was 1 in CG X EG-pre (95% CI, 1.000–1.000; p 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2020.08.006