Nickel/briphos-catalyzed transamidation of unactivated tertiary amides

Nickel/briphos-catalyzed transamidation of unactivated tertiary amides

The transamidation of tertiary amides was achieved via nickel catalysis in combination with briphos ligands. N -Methyl- N -phenylbenzamide derivatives reacted with primary amines in the presence of NiCl 2 /briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic...

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Veröffentlicht in:Organic & biomolecular chemistry 2020-08, Vol.18 (31), p.653-657
Hauptverfasser: Yang, Dahyeon, Shin, Taeil, Kim, Hyunwoo, Lee, Sunwoo
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic amines
Amides
Amines
Catalysis
Nickel
Nickel chloride
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Zusammenfassung:The transamidation of tertiary amides was achieved via nickel catalysis in combination with briphos ligands. N -Methyl- N -phenylbenzamide derivatives reacted with primary amines in the presence of NiCl 2 /briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines. The transamidation of tertiary amides was achieved via nickel catalysis in combination with briphos ligands.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob01271h