The prognostic role of soluble transforming growth factor‐β and its correlation with soluble programmed death‐ligand 1 in biliary tract cancer

Background This study aimed to evaluate the association between soluble TGF‐β (sTGF‐β) and soluble PD‐L1 (sPDL1), the dynamics of sTGF‐β during treatment and its prognostic role in biliary tract cancer (BTC). Methods The study population consisted of 90 BTC patients with first‐line chemotherapy (coh...

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Veröffentlicht in:	Liver international 2021-02, Vol.41 (2), p.388-395
Hauptverfasser:	Kim, Jin Won, Lee, Kyung‐Hun, Kim, Ji‐Won, Suh, Koung Jin, Nam, Ah‐Rong, Bang, Ju‐Hee, Jin, Mei Hua, Oh, Kyoung‐Seok, Kim, Jae‐Min, Kim, Tae‐Yong, Oh, Do‐Youn
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen Biliary tract biliary tract cancer Biliary Tract Neoplasms - drug therapy Cancer Chemotherapy Correlation Growth factors Humans Medical prognosis Medical treatment PD-L1 protein Population studies Prognosis sPDL1 sTGF‐β Transforming Growth Factor beta Transforming growth factor-b Transforming Growth Factors Tumors tumour burden
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Zusammenfassung:	Background This study aimed to evaluate the association between soluble TGF‐β (sTGF‐β) and soluble PD‐L1 (sPDL1), the dynamics of sTGF‐β during treatment and its prognostic role in biliary tract cancer (BTC). Methods The study population consisted of 90 BTC patients with first‐line chemotherapy (cohort 1) and 35 BTC patients with second‐ or third‐line chemotherapy (cohort 2). Plasma sTGF‐β and sPDL1 levels were measured using an enzyme‐linked immunosorbent assay. Results In both groups, sTGF‐β was positive correlated with sPDL1 for baseline and change values after treatment. sTGF‐β was elevated at disease progression compared to baseline in cohort 1 (P
ISSN:	1478-3223 1478-3231
DOI:	10.1111/liv.14636