Altered cardiac repolarisation in highlanders with high‐altitude pulmonary hypertension during wakefulness and sleep

Altered cardiac repolarisation in highlanders with high‐altitude pulmonary hypertension during wakefulness and sleep

High‐altitude pulmonary hypertension (HAPH) is an altitude‐related illness associated with hypoxaemia that may promote sympathetic excitation and prolongation of the QT interval. The present case‐control study tests whether QT intervals, markers of malignant cardiac arrhythmias, are prolonged in hig...

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Veröffentlicht in:Journal of sleep research 2021-06, Vol.30 (3), p.e13153-n/a
Hauptverfasser: Aeschbacher, Sayaka S., Latshang, Tsogyal D., Sheraliev, Ulan, Marazhapov, Nuriddin H., Ulrich, Silvia, Sooronbaev, Talant M., Bloch, Konrad E., Furian, Michael
Format: Artikel
Sprache:eng
Schlagworte:
high‐altitude illness
high‐altitude pulmonary hypertension
hypoxaemia
QTc prolongation
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Zusammenfassung:High‐altitude pulmonary hypertension (HAPH) is an altitude‐related illness associated with hypoxaemia that may promote sympathetic excitation and prolongation of the QT interval. The present case‐control study tests whether QT intervals, markers of malignant cardiac arrhythmias, are prolonged in highlanders with HAPH (HAPH+) compared to healthy highlanders (HH) and healthy lowlanders (LL). The mean pulmonary artery pressure (mPAP) was measured by echocardiography in 18 HAPH+ (mPAP, 34 mmHg) and 18 HH (mPAP, 23 mmHg) at 3,250 m, and 18 LL (mPAP, 18 mmHg) at 760 m, Kyrgyzstan (p 
ISSN:0962-1105
1365-2869
DOI:10.1111/jsr.13153