First, tau causes NO problem

Pathological tau disrupts the association between nitric oxide (NO) synthase and PSD95, impairing NO signaling and neurovascular coupling before causing neurodegeneration. Stopping production of pathological tau rescues NO signaling, neurovascular coupling and neuronal function, but doesn’t remove t...

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Veröffentlicht in:	Nature neuroscience 2020-09, Vol.23 (9), p.1035-1036
Hauptverfasser:	Bonnar, Orla, Hall, Catherine N.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/132 631/378/2607 Alzheimer's disease Amyloid Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Cerebral circulation Clinical pathology Cognitive ability Coupling Dementia Disks Large Homolog 4 Protein Health aspects Measurement Neurobiology Neurodegeneration Neurons Neurosciences News & Views news-and-views Nitric oxide Pathology Postsynaptic density proteins Proteins Signaling Tau protein Tau proteins Transcription Factors
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Beschreibung
Zusammenfassung:	Pathological tau disrupts the association between nitric oxide (NO) synthase and PSD95, impairing NO signaling and neurovascular coupling before causing neurodegeneration. Stopping production of pathological tau rescues NO signaling, neurovascular coupling and neuronal function, but doesn’t remove tangles, suggesting that (like amyloid-β) soluble tau is an important driver of early neurovascular dysfunction and subsequent neuronal damage.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/s41593-020-0691-x