Scaling-up of Haematococcus pluvialis production in stirred tank photobioreactor

•H. pluvialis was cultivated in cultivation bottles and stirred tank PBRs.•Constant P/V, tm and kLa as scale-up criteria were evaluated.•Constant P/V criterion resulted in maximum carotenoid production per biomass.•Similar yield between cultivation bottle and PBR proved a successful scale-up.•Maximu...

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Veröffentlicht in:Bioresource technology 2020-08, Vol.310, p.123434-123434, Article 123434
1. Verfasser: Deniz, Irem
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Sprache:eng
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Zusammenfassung:•H. pluvialis was cultivated in cultivation bottles and stirred tank PBRs.•Constant P/V, tm and kLa as scale-up criteria were evaluated.•Constant P/V criterion resulted in maximum carotenoid production per biomass.•Similar yield between cultivation bottle and PBR proved a successful scale-up.•Maximum antioxidant effect of extract was achieved with constant P/V strategy. The objective of this study was to evaluate three most common scale-up criteria for Haematococcus pluvialis production from cultivation bottles to 2 and 10 L of stirred tank PBRs. Constant volumetric power input (P/V) was found to be the most suitable criterion for H. pluvialis production. Total carotenoid amount per biomass concentration in 2 L and 10 L stirred tank PBRs were determined to be 4.57 mg/g and 4.77 mg/g, respectively. Antioxidant activity of total carotenoids extracted from H. pluvialis was also higher at constant P/V criterion where 46.91% inhibition rate with a total phenolic content of 11.76 mg gallic acid/L was achieved. Obtained results could be used to expand the bioproduction of H. pluvialis and its extracts in commercial scale.
ISSN:0960-8524
1873-2976
DOI:10.1016/j.biortech.2020.123434