Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications

The discovery of NO, CO, and H 2 S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously delivering them as therapeutic agents. However, the gaseous nature of these molecules demands new forms of administration that enable...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (68), p.975-9766
Hauptverfasser: Carné-Sánchez, Arnau, Carmona, Francisco J, Kim, Chiwon, Furukawa, Shuhei
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Sprache:eng
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Zusammenfassung:The discovery of NO, CO, and H 2 S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously delivering them as therapeutic agents. However, the gaseous nature of these molecules demands new forms of administration that enable one to control the location, dosage and timing of their delivery. Porous materials are among the most suitable scaffolds to store, deliver and release gasotransmitters due to their high surface area, tunable composition and reactivity. This review highlights the strategies employed to load and release gasotransmitters from different kinds of porous materials, including zeolites, mesoporous silica, metal-organic frameworks and protein assemblies. This review highlights the strategies employed to load and release gasotransmitters such as NO, CO and H 2 S from different kinds of porous materials, including zeolites, mesoporous silica, metal-organic frameworks and protein assemblies.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03740k