The association between bacterial infections and the risk of coronary heart disease in type 1 diabetes
Background Diabetes increases the risk of infections and coronary heart disease (CHD). Whether infections increase the risk of CHD and how this applies to individuals with diabetes is unclear. Objectives To investigate the association between bacterial infections and the risk of CHD in type 1 diabet...
Gespeichert in:
Veröffentlicht in: | Journal of internal medicine 2020-12, Vol.288 (6), p.711-724 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Background
Diabetes increases the risk of infections and coronary heart disease (CHD). Whether infections increase the risk of CHD and how this applies to individuals with diabetes is unclear.
Objectives
To investigate the association between bacterial infections and the risk of CHD in type 1 diabetes.
Methods
Individuals with type 1 diabetes (n = 3781) were recruited from the Finnish Diabetic Nephropathy Study (FinnDiane), a prospective follow‐up study. CHD was defined as incident events: fatal or nonfatal myocardial infarction, coronary artery bypass surgery or percutaneous coronary intervention, identified through national hospital discharge register data. Infections were identified through national register data on all antibiotic purchases from outpatient care. Register data were available from 1 January 1995 to 31 December 2015. Bacterial lipopolysaccharide (LPS) activity was measured from serum samples at baseline. Data on traditional risk factors for CHD were collected during baseline and consecutive visits.
Results
Individuals with an incident CHD event (n = 370) had a higher mean number of antibiotic purchases per follow‐up year compared to those without incident CHD (1.34 [95% CI: 1.16–1.52], versus 0.79 [0.76–0.82], P |
---|---|
ISSN: | 0954-6820 1365-2796 |
DOI: | 10.1111/joim.13138 |