Editorial commentary: Arrhythmogenic cardiomyopathy: An in-depth look at molecular mechanisms and clinical correlates

[...]the identification of anti-Dsg2 auto-antibodies in ACM adds further evidence to the belief that inflammation is not a secondary phenomenon, but rather a driving force of the disease [17]. [...]ACM is a major cause of SCD but current treatment remains largely empirical, aiming to prevent life-threatening arrhythmias and heart failure. The development of multiple experimental models has accelerated our understanding of these pathways but large knowledge gaps exist. [...]a genetic cause is yet to be identified in almost half of diagnosed patients.