Ferritin in hemophagocytic lymphohistiocytosis (HLH): current concepts and controversies

Ferritin in hemophagocytic lymphohistiocytosis (HLH): current concepts and controversies

•Hemophagocytic lymphohistiocytosis (HLH) is a state of hyperinflammatory state.•Hyperferritinemia (≥500 ng/ml) has been incorporated as a criterion in diagnosis.•≥10,000 ng/ml ferritin is diagnostic of pediatric HLH.•Adult HLH is heterogeneous disease with diverse etiologies and >2000 ng/ml ferr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinica chimica acta 2020-11, Vol.510, p.408-415
Hauptverfasser: Sarangi, RajLaxmi, Pathak, Mona, Padhi, Somanath, Mahapatra, Srikrushna
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Hemophagocytic lymphohistiocytosis (HLH) is a state of hyperinflammatory state.•Hyperferritinemia (≥500 ng/ml) has been incorporated as a criterion in diagnosis.•≥10,000 ng/ml ferritin is diagnostic of pediatric HLH.•Adult HLH is heterogeneous disease with diverse etiologies and >2000 ng/ml ferritin may be more relevant.•Raising ferritin cut off might be considered for incorporating in HLH diagnostic criteria.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2020.07.053