Prospecting for molecular glues
Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.
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| Veröffentlicht in: | Nature chemical biology 2020-11, Vol.16 (11), p.1157-1158 |
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| container_title | Nature chemical biology |
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| creator | den Besten, Willem Lipford, J. Russell |
| description | Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation. |
| doi_str_mv | 10.1038/s41589-020-0620-z |
| format | Article |
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| subjects | 631/45 631/92/275 631/92/613 631/92/93 Adhesives Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclins Estrogens Exploration Glues Kinases Ligands News & Views news-and-views Proteins Ubiquitin Ubiquitin-protein ligase |
| title | Prospecting for molecular glues |
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