Prospecting for molecular glues

Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2020-11, Vol.16 (11), p.1157-1158
Hauptverfasser:	den Besten, Willem, Lipford, J. Russell
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/92/275 631/92/613 631/92/93 Adhesives Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclins Estrogens Exploration Glues Kinases Ligands News & Views news-and-views Proteins Ubiquitin Ubiquitin-protein ligase
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Beschreibung
Zusammenfassung:	Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/s41589-020-0620-z