Multifunctional nanoparticles in stem cell therapy for cellular treating of kidney and liver diseases

[Display omitted] •Trails about using nanoparticles in stem cell therapy in kidney and liver diseases were indicated.•An overview of the mechanisms of distribution of nanoparticles in stem cells was achieved.•Tracking the fate of transplanted stem cells by using various techniques also was discussed.•The distinctive strategies to enhance homing of labeled stem cells with nanoparticles were explained.•How to improve nanoparticles uptake by making modifications to iron coat was illustrated. The review gives an overview of the mechanisms of internalization and distribution of nanoparticles in stem cells this is achieved via providing analysis of the methods used in exploring the migration routes of stem cells, and their reciprocity. In addition, exploring microenvironment target in the body, and tracking the fate of exogenously transplanted stem cells by using innovative and non-invasive techniques will also be discussed. Such techniques like magnetic resonance imaging (MRI), multimodality tracking, optical imaging, and nuclear medicine imaging, which were designed to follow up stem cell migration. This review will explain the various distinctive strategies to enhance homing of labeled stem cells with nanoparticles into damaged hepatic and renal tissues, this purpose was obtained by inducing a specific gene into stem cells, various chemokines, and applying an external magnetic field. Also, this work illustrates how to improve nanoparticles uptake by using transfection agents or covalently binding an exogenous protein (i.e., Human immunodeficiency virus–Tat protein) or conjugating a receptor-specific monoclonal antibody or make modifications to iron coat. It contains stem cell labeling methods such as extracellular labeling and internalization approaches. Ultimately, our review indicates trails of researchers in nanoparticles utilization in stem cell therapy in both kidney and liver diseases.