Engineering nanoparticulate vaccines for enhancing antigen cross-presentation

Engineering nanoparticulate vaccines for enhancing antigen cross-presentation

Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming. In th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in biotechnology 2020-12, Vol.66, p.113-122
Hauptverfasser: Du, Guangsheng, Sun, Xun
Format: Artikel
Sprache:eng
Schlagworte:
Antigen Presentation
CD8-Positive T-Lymphocytes
Cross-Priming
Dendritic Cells
Vaccines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 122
container_issue
container_start_page 113
container_title Current opinion in biotechnology
container_volume 66
creator Du, Guangsheng
Sun, Xun
description Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming. In this review, we will summarize the known intracellular pathways involved in cross-presentation, and focus on several nanoparticle strategies that have been reported for enhancing cross-presentation, including designing multifunctional nano-vaccines for increasing endosomal escape, designing nano-vaccines that can target lymph nodes to improve antigen uptake by lymph node resident CD8α+ dendritic cells, and co-delivering immune modulators for upregulating cross-presentation related intracellular components. We will also briefly discuss the future prospects of cross-presentation based nano-vaccine strategy for curing diseases.
doi_str_mv 10.1016/j.copbio.2020.06.015
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2430370902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0958166920300884</els_id><sourcerecordid>2430370902</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-97d238bdb1b55c3c08567de851d48919b7429d51799a1e19f0116d3bd252ece13</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwDxDKyJJwduIkXpAQKh9SEQvMlmNfi6vWDnZSiX9PSgoj0w333Mf7EHJJIaNAy5t1pn3bWJ8xYJBBmQHlR2RK60qkUDBxTKYgeJ3SshQTchbjGgB4XsEpmeSsKnhdiyl5mbuVdYjBulXilPOtCp3V_UZ1mOyU1kMzJksfEnQfyuk9plxnV-gSHXyMaRswoutUZ707JydLtYl4cagz8v4wf7t_Shevj8_3d4tU5yXrUlEZlteNaWjDuc411LysDNacmqIWVDTV8L_htBJCUaRiCZSWJm8M4ww10nxGrse9bfCfPcZObm3UuNkoh76PkhU5DEkFsAEtRvTn24BL2Qa7VeFLUpB7kXItR5FyL1JCKQeRw9jV4ULfbNH8Df2aG4DbEcAh585ikFFbdBqNDag7abz9_8I3jlmGxg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430370902</pqid></control><display><type>article</type><title>Engineering nanoparticulate vaccines for enhancing antigen cross-presentation</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Du, Guangsheng ; Sun, Xun</creator><creatorcontrib>Du, Guangsheng ; Sun, Xun</creatorcontrib><description>Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming. In this review, we will summarize the known intracellular pathways involved in cross-presentation, and focus on several nanoparticle strategies that have been reported for enhancing cross-presentation, including designing multifunctional nano-vaccines for increasing endosomal escape, designing nano-vaccines that can target lymph nodes to improve antigen uptake by lymph node resident CD8α+ dendritic cells, and co-delivering immune modulators for upregulating cross-presentation related intracellular components. We will also briefly discuss the future prospects of cross-presentation based nano-vaccine strategy for curing diseases.</description><identifier>ISSN: 0958-1669</identifier><identifier>EISSN: 1879-0429</identifier><identifier>DOI: 10.1016/j.copbio.2020.06.015</identifier><identifier>PMID: 32745889</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antigen Presentation ; CD8-Positive T-Lymphocytes ; Cross-Priming ; Dendritic Cells ; Vaccines</subject><ispartof>Current opinion in biotechnology, 2020-12, Vol.66, p.113-122</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-97d238bdb1b55c3c08567de851d48919b7429d51799a1e19f0116d3bd252ece13</citedby><cites>FETCH-LOGICAL-c362t-97d238bdb1b55c3c08567de851d48919b7429d51799a1e19f0116d3bd252ece13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.copbio.2020.06.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32745889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Guangsheng</creatorcontrib><creatorcontrib>Sun, Xun</creatorcontrib><title>Engineering nanoparticulate vaccines for enhancing antigen cross-presentation</title><title>Current opinion in biotechnology</title><addtitle>Curr Opin Biotechnol</addtitle><description>Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming. In this review, we will summarize the known intracellular pathways involved in cross-presentation, and focus on several nanoparticle strategies that have been reported for enhancing cross-presentation, including designing multifunctional nano-vaccines for increasing endosomal escape, designing nano-vaccines that can target lymph nodes to improve antigen uptake by lymph node resident CD8α+ dendritic cells, and co-delivering immune modulators for upregulating cross-presentation related intracellular components. We will also briefly discuss the future prospects of cross-presentation based nano-vaccine strategy for curing diseases.</description><subject>Antigen Presentation</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Cross-Priming</subject><subject>Dendritic Cells</subject><subject>Vaccines</subject><issn>0958-1669</issn><issn>1879-0429</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwDxDKyJJwduIkXpAQKh9SEQvMlmNfi6vWDnZSiX9PSgoj0w333Mf7EHJJIaNAy5t1pn3bWJ8xYJBBmQHlR2RK60qkUDBxTKYgeJ3SshQTchbjGgB4XsEpmeSsKnhdiyl5mbuVdYjBulXilPOtCp3V_UZ1mOyU1kMzJksfEnQfyuk9plxnV-gSHXyMaRswoutUZ707JydLtYl4cagz8v4wf7t_Shevj8_3d4tU5yXrUlEZlteNaWjDuc411LysDNacmqIWVDTV8L_htBJCUaRiCZSWJm8M4ww10nxGrse9bfCfPcZObm3UuNkoh76PkhU5DEkFsAEtRvTn24BL2Qa7VeFLUpB7kXItR5FyL1JCKQeRw9jV4ULfbNH8Df2aG4DbEcAh585ikFFbdBqNDag7abz9_8I3jlmGxg</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Du, Guangsheng</creator><creator>Sun, Xun</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Engineering nanoparticulate vaccines for enhancing antigen cross-presentation</title><author>Du, Guangsheng ; Sun, Xun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-97d238bdb1b55c3c08567de851d48919b7429d51799a1e19f0116d3bd252ece13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigen Presentation</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Cross-Priming</topic><topic>Dendritic Cells</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Guangsheng</creatorcontrib><creatorcontrib>Sun, Xun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Guangsheng</au><au>Sun, Xun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering nanoparticulate vaccines for enhancing antigen cross-presentation</atitle><jtitle>Current opinion in biotechnology</jtitle><addtitle>Curr Opin Biotechnol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>66</volume><spage>113</spage><epage>122</epage><pages>113-122</pages><issn>0958-1669</issn><eissn>1879-0429</eissn><abstract>Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming. In this review, we will summarize the known intracellular pathways involved in cross-presentation, and focus on several nanoparticle strategies that have been reported for enhancing cross-presentation, including designing multifunctional nano-vaccines for increasing endosomal escape, designing nano-vaccines that can target lymph nodes to improve antigen uptake by lymph node resident CD8α+ dendritic cells, and co-delivering immune modulators for upregulating cross-presentation related intracellular components. We will also briefly discuss the future prospects of cross-presentation based nano-vaccine strategy for curing diseases.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32745889</pmid><doi>10.1016/j.copbio.2020.06.015</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0958-1669
ispartof Current opinion in biotechnology, 2020-12, Vol.66, p.113-122
issn 0958-1669
1879-0429
language eng
recordid cdi_proquest_miscellaneous_2430370902
source Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE
subjects Antigen Presentation
CD8-Positive T-Lymphocytes
Cross-Priming
Dendritic Cells
Vaccines
title Engineering nanoparticulate vaccines for enhancing antigen cross-presentation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T05%3A08%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Engineering%20nanoparticulate%20vaccines%20for%20enhancing%20antigen%20cross-presentation&rft.jtitle=Current%20opinion%20in%20biotechnology&rft.au=Du,%20Guangsheng&rft.date=2020-12&rft.volume=66&rft.spage=113&rft.epage=122&rft.pages=113-122&rft.issn=0958-1669&rft.eissn=1879-0429&rft_id=info:doi/10.1016/j.copbio.2020.06.015&rft_dat=%3Cproquest_cross%3E2430370902%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2430370902&rft_id=info:pmid/32745889&rft_els_id=S0958166920300884&rfr_iscdi=true