Prognostic value of postoperative serum carcinoembryonic antigen levels in colorectal cancer patients with chronic kidney disease

Chronic kidney disease (CKD) can increase serum carcinoembryonic antigen (CEA) levels. We thus aimed to evaluate the impact of CKD on CEA prognostic accuracy in colorectal cancer. Altogether, 429 patients who underwent curative resection for stages I–III colorectal adenocarcinoma were grouped accord...

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Veröffentlicht in:	The American journal of surgery 2021-01, Vol.221 (1), p.162-167
Hauptverfasser:	Huang, Chih-Sheng, Huang, Li-Kuo, Chen, Chin-Yau, Wang, Wei-Shu, Yang, Shung-Haur
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - blood Adenocarcinoma - complications Adenocarcinoma - mortality Adenocarcinoma - surgery Adult Age Aged Aged, 80 and over Antigens Biomarkers Cancer Cancer therapies Carcinoembryonic antigen Carcinoembryonic Antigen - blood Chemotherapy Chronic kidney disease Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - complications Colorectal Neoplasms - mortality Colorectal Neoplasms - surgery Confidence intervals Diabetes Disease-Free Survival Female Humans Kidney diseases Kidneys Male Medical prognosis Middle Aged Patients Postoperative Period Prognosis Regression analysis Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Retrospective Studies Software Surgery Tumors
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Zusammenfassung:	Chronic kidney disease (CKD) can increase serum carcinoembryonic antigen (CEA) levels. We thus aimed to evaluate the impact of CKD on CEA prognostic accuracy in colorectal cancer. Altogether, 429 patients who underwent curative resection for stages I–III colorectal adenocarcinoma were grouped according to postoperative CEA levels and history of CKD. Three-year disease-free survival (DFS) was higher in patients with normal postoperative CEA (group A, 83.4%) than in those with elevated postoperative CEA (group B, 64.3%) (p
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2020.07.015