Make killers sweeter: targeting metabolic checkpoints of NK cells
Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.
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| Veröffentlicht in: | Nature immunology 2020-09, Vol.21 (9), p.970-971 |
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| container_end_page | 971 |
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| container_title | Nature immunology |
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| creator | Wei, Haiming Fu, Binqing |
| description | Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism. |
| doi_str_mv | 10.1038/s41590-020-0738-x |
| format | Article |
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| subjects | 631/250/1619/382 631/250/2504/2506 631/250/347 631/250/580 Biomedical and Life Sciences Biomedicine Carcinogenesis Cell metabolism Health aspects Immune response Immunity, Innate Immunology Infectious Diseases Killer cells Killer Cells, Natural Leukocytes (eosinophilic) Lymphoid cells Metabolism Natural killer cells News & Views news-and-views Observations |
| title | Make killers sweeter: targeting metabolic checkpoints of NK cells |
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