Make killers sweeter: targeting metabolic checkpoints of NK cells

Make killers sweeter: targeting metabolic checkpoints of NK cells

Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2020-09, Vol.21 (9), p.970-971
Hauptverfasser: Wei, Haiming, Fu, Binqing
Format: Artikel
Sprache:eng
Schlagworte:
631/250/1619/382
631/250/2504/2506
631/250/347
631/250/580
Biomedical and Life Sciences
Biomedicine
Carcinogenesis
Cell metabolism
Health aspects
Immune response
Immunity, Innate
Immunology
Infectious Diseases
Killer cells
Killer Cells, Natural
Leukocytes (eosinophilic)
Lymphoid cells
Metabolism
Natural killer cells
News & Views
news-and-views
Observations
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-020-0738-x