Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis
Objectives The objective of this study was to analyze the predictive value of the modified Bhalla score in high-resolution computed tomography (HRCT) for assessment of pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients. We also describe the relationship between this score and pulmonary f...
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| Veröffentlicht in: | European radiology 2021, Vol.31 (1), p.112-120 |
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| creator | Diab-Cáceres, Layla Girón-Moreno, Rosa María García-Castillo, Elena Pastor-Sanz, Maria Teresa Olveira, Casilda García-Clemente, Marta María Nieto-Royo, Rosa Prados-Sánchez, Concha Caballero-Sánchez, Paloma Olivera-Serrano, Maria Jose Padilla-Galo, Alicia Nava-Tomas, Encarnacion Esteban-Peris, Amparo Fernández-Velilla, Maria Torres, Maribel Gómez-Punter, Rosa Mar Ancochea, Julio |
| description | Objectives
The objective of this study was to analyze the predictive value of the modified Bhalla score in high-resolution computed tomography (HRCT) for assessment of pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients. We also describe the relationship between this score and pulmonary function test results.
Methods
We performed a multicenter and prospective study where adult patients with CF were included consecutively over 18 months. All patients underwent HRCT with acquisition in inspiration and expiration. The results were analyzed by an expert radiologist who assigned a modified Bhalla score value. Lung function was also assessed, and clinical variables were collected. Follow-up lasted approximately 1 year, and PEx were registered.
Results
The study population comprised 160 subjects selected from 360 CF patients monitored in the participating CF units. The mean age was 28 years, 47.5% were women, and mean forced expiratory volume in 1 s (FEV
1
) was 67.5%. The mean global modified Bhalla score was 14.5 ± 0.31 points. Pulmonary function test (PFT) results and the modified Bhalla score correlated well, mainly forced vital capacity (FVC) and FEV
1
. We constructed a statistical model based on the overall Bhalla score to predict the number of PEx.
Conclusions
The overall modified Bhalla score can predict future PEx in CF patients. This useful tool can help to prevent PEx in higher risk patients.
Key Points
• Pulmonary function test results and the modified Bhalla score correlated well with FVC and FEV
1
.
• The total modified Bhalla score can predict the number of exacerbations in adult CF patients.
• Our findings highlight the need to establish a unified protocol for chest HRCT during the follow-up of adult patients with CF in order to anticipate possible complications and determine their impact on pulmonary function. |
| doi_str_mv | 10.1007/s00330-020-07095-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2430101166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2473393712</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-dc37c243cdac05cce2b084b946ac8119069b8bd21fe07fbbb8182c6817ee39b43</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EotvCC3BAlrhwCYztbBwfoYKCVAkOcLZsZ8K6SuLF42zZt8dlC0gcOFhz8De__etj7JmAVwJAvyYApaABWY8Gs22OD9hGtEo2Avr2IduAUX2jjWnP2DnRDQAY0erH7ExJ3UIvtht2-JxxiKHEA_KDm1bkaeRlh3xOQxwjDvztzk2T4xRSRj6mzB0REs24lDt2v05zWlw-cvzhAmbvSkwL8bhwN6xTIX4by46HI5UY-Bh9ThTpCXs0uonw6f28YF_fv_ty-aG5_nT18fLNdROU3pZmqCPIVoXBBdiGgNLXZt60nQu9EAY643s_SDEi6NF734tehq4XGlEZ36oL9vKUu8_p-4pU7BwpYC20YFrJ1mwQIETXVfTFP-hNWvNSf1cprZRRWshKyRMVag_KONp9jnOtbwXYOyv2ZMVWK_aXFXusS8_vo1c_4_Bn5beGCqgTQPVq-Yb579v_if0Jh_OaHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473393712</pqid></control><display><type>article</type><title>Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Diab-Cáceres, Layla ; Girón-Moreno, Rosa María ; García-Castillo, Elena ; Pastor-Sanz, Maria Teresa ; Olveira, Casilda ; García-Clemente, Marta María ; Nieto-Royo, Rosa ; Prados-Sánchez, Concha ; Caballero-Sánchez, Paloma ; Olivera-Serrano, Maria Jose ; Padilla-Galo, Alicia ; Nava-Tomas, Encarnacion ; Esteban-Peris, Amparo ; Fernández-Velilla, Maria ; Torres, Maribel ; Gómez-Punter, Rosa Mar ; Ancochea, Julio</creator><creatorcontrib>Diab-Cáceres, Layla ; Girón-Moreno, Rosa María ; García-Castillo, Elena ; Pastor-Sanz, Maria Teresa ; Olveira, Casilda ; García-Clemente, Marta María ; Nieto-Royo, Rosa ; Prados-Sánchez, Concha ; Caballero-Sánchez, Paloma ; Olivera-Serrano, Maria Jose ; Padilla-Galo, Alicia ; Nava-Tomas, Encarnacion ; Esteban-Peris, Amparo ; Fernández-Velilla, Maria ; Torres, Maribel ; Gómez-Punter, Rosa Mar ; Ancochea, Julio</creatorcontrib><description>Objectives
The objective of this study was to analyze the predictive value of the modified Bhalla score in high-resolution computed tomography (HRCT) for assessment of pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients. We also describe the relationship between this score and pulmonary function test results.
Methods
We performed a multicenter and prospective study where adult patients with CF were included consecutively over 18 months. All patients underwent HRCT with acquisition in inspiration and expiration. The results were analyzed by an expert radiologist who assigned a modified Bhalla score value. Lung function was also assessed, and clinical variables were collected. Follow-up lasted approximately 1 year, and PEx were registered.
Results
The study population comprised 160 subjects selected from 360 CF patients monitored in the participating CF units. The mean age was 28 years, 47.5% were women, and mean forced expiratory volume in 1 s (FEV
1
) was 67.5%. The mean global modified Bhalla score was 14.5 ± 0.31 points. Pulmonary function test (PFT) results and the modified Bhalla score correlated well, mainly forced vital capacity (FVC) and FEV
1
. We constructed a statistical model based on the overall Bhalla score to predict the number of PEx.
Conclusions
The overall modified Bhalla score can predict future PEx in CF patients. This useful tool can help to prevent PEx in higher risk patients.
Key Points
• Pulmonary function test results and the modified Bhalla score correlated well with FVC and FEV
1
.
• The total modified Bhalla score can predict the number of exacerbations in adult CF patients.
• Our findings highlight the need to establish a unified protocol for chest HRCT during the follow-up of adult patients with CF in order to anticipate possible complications and determine their impact on pulmonary function.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-020-07095-y</identifier><identifier>PMID: 32740815</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Complications ; Computed Tomography ; Correlation analysis ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - diagnostic imaging ; Diagnostic Radiology ; Female ; Forced Expiratory Volume ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Lung - diagnostic imaging ; Male ; Mathematical models ; Medicine ; Medicine & Public Health ; Neuroradiology ; Population studies ; Prospective Studies ; Pulmonary functions ; Radiology ; Respiratory function ; Statistical models ; Ultrasound ; Vital Capacity</subject><ispartof>European radiology, 2021, Vol.31 (1), p.112-120</ispartof><rights>European Society of Radiology 2020</rights><rights>European Society of Radiology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dc37c243cdac05cce2b084b946ac8119069b8bd21fe07fbbb8182c6817ee39b43</citedby><cites>FETCH-LOGICAL-c375t-dc37c243cdac05cce2b084b946ac8119069b8bd21fe07fbbb8182c6817ee39b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-020-07095-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-020-07095-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32740815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diab-Cáceres, Layla</creatorcontrib><creatorcontrib>Girón-Moreno, Rosa María</creatorcontrib><creatorcontrib>García-Castillo, Elena</creatorcontrib><creatorcontrib>Pastor-Sanz, Maria Teresa</creatorcontrib><creatorcontrib>Olveira, Casilda</creatorcontrib><creatorcontrib>García-Clemente, Marta María</creatorcontrib><creatorcontrib>Nieto-Royo, Rosa</creatorcontrib><creatorcontrib>Prados-Sánchez, Concha</creatorcontrib><creatorcontrib>Caballero-Sánchez, Paloma</creatorcontrib><creatorcontrib>Olivera-Serrano, Maria Jose</creatorcontrib><creatorcontrib>Padilla-Galo, Alicia</creatorcontrib><creatorcontrib>Nava-Tomas, Encarnacion</creatorcontrib><creatorcontrib>Esteban-Peris, Amparo</creatorcontrib><creatorcontrib>Fernández-Velilla, Maria</creatorcontrib><creatorcontrib>Torres, Maribel</creatorcontrib><creatorcontrib>Gómez-Punter, Rosa Mar</creatorcontrib><creatorcontrib>Ancochea, Julio</creatorcontrib><title>Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
The objective of this study was to analyze the predictive value of the modified Bhalla score in high-resolution computed tomography (HRCT) for assessment of pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients. We also describe the relationship between this score and pulmonary function test results.
Methods
We performed a multicenter and prospective study where adult patients with CF were included consecutively over 18 months. All patients underwent HRCT with acquisition in inspiration and expiration. The results were analyzed by an expert radiologist who assigned a modified Bhalla score value. Lung function was also assessed, and clinical variables were collected. Follow-up lasted approximately 1 year, and PEx were registered.
Results
The study population comprised 160 subjects selected from 360 CF patients monitored in the participating CF units. The mean age was 28 years, 47.5% were women, and mean forced expiratory volume in 1 s (FEV
1
) was 67.5%. The mean global modified Bhalla score was 14.5 ± 0.31 points. Pulmonary function test (PFT) results and the modified Bhalla score correlated well, mainly forced vital capacity (FVC) and FEV
1
. We constructed a statistical model based on the overall Bhalla score to predict the number of PEx.
Conclusions
The overall modified Bhalla score can predict future PEx in CF patients. This useful tool can help to prevent PEx in higher risk patients.
Key Points
• Pulmonary function test results and the modified Bhalla score correlated well with FVC and FEV
1
.
• The total modified Bhalla score can predict the number of exacerbations in adult CF patients.
• Our findings highlight the need to establish a unified protocol for chest HRCT during the follow-up of adult patients with CF in order to anticipate possible complications and determine their impact on pulmonary function.</description><subject>Adult</subject><subject>Complications</subject><subject>Computed Tomography</subject><subject>Correlation analysis</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - diagnostic imaging</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Lung - diagnostic imaging</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Pulmonary functions</subject><subject>Radiology</subject><subject>Respiratory function</subject><subject>Statistical models</subject><subject>Ultrasound</subject><subject>Vital Capacity</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu1DAQhi0EotvCC3BAlrhwCYztbBwfoYKCVAkOcLZsZ8K6SuLF42zZt8dlC0gcOFhz8De__etj7JmAVwJAvyYApaABWY8Gs22OD9hGtEo2Avr2IduAUX2jjWnP2DnRDQAY0erH7ExJ3UIvtht2-JxxiKHEA_KDm1bkaeRlh3xOQxwjDvztzk2T4xRSRj6mzB0REs24lDt2v05zWlw-cvzhAmbvSkwL8bhwN6xTIX4by46HI5UY-Bh9ThTpCXs0uonw6f28YF_fv_ty-aG5_nT18fLNdROU3pZmqCPIVoXBBdiGgNLXZt60nQu9EAY643s_SDEi6NF734tehq4XGlEZ36oL9vKUu8_p-4pU7BwpYC20YFrJ1mwQIETXVfTFP-hNWvNSf1cprZRRWshKyRMVag_KONp9jnOtbwXYOyv2ZMVWK_aXFXusS8_vo1c_4_Bn5beGCqgTQPVq-Yb579v_if0Jh_OaHg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Diab-Cáceres, Layla</creator><creator>Girón-Moreno, Rosa María</creator><creator>García-Castillo, Elena</creator><creator>Pastor-Sanz, Maria Teresa</creator><creator>Olveira, Casilda</creator><creator>García-Clemente, Marta María</creator><creator>Nieto-Royo, Rosa</creator><creator>Prados-Sánchez, Concha</creator><creator>Caballero-Sánchez, Paloma</creator><creator>Olivera-Serrano, Maria Jose</creator><creator>Padilla-Galo, Alicia</creator><creator>Nava-Tomas, Encarnacion</creator><creator>Esteban-Peris, Amparo</creator><creator>Fernández-Velilla, Maria</creator><creator>Torres, Maribel</creator><creator>Gómez-Punter, Rosa Mar</creator><creator>Ancochea, Julio</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2021</creationdate><title>Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis</title><author>Diab-Cáceres, Layla ; Girón-Moreno, Rosa María ; García-Castillo, Elena ; Pastor-Sanz, Maria Teresa ; Olveira, Casilda ; García-Clemente, Marta María ; Nieto-Royo, Rosa ; Prados-Sánchez, Concha ; Caballero-Sánchez, Paloma ; Olivera-Serrano, Maria Jose ; Padilla-Galo, Alicia ; Nava-Tomas, Encarnacion ; Esteban-Peris, Amparo ; Fernández-Velilla, Maria ; Torres, Maribel ; Gómez-Punter, Rosa Mar ; Ancochea, Julio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-dc37c243cdac05cce2b084b946ac8119069b8bd21fe07fbbb8182c6817ee39b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Complications</topic><topic>Computed Tomography</topic><topic>Correlation analysis</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - diagnostic imaging</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Lung - diagnostic imaging</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Population studies</topic><topic>Prospective Studies</topic><topic>Pulmonary functions</topic><topic>Radiology</topic><topic>Respiratory function</topic><topic>Statistical models</topic><topic>Ultrasound</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diab-Cáceres, Layla</creatorcontrib><creatorcontrib>Girón-Moreno, Rosa María</creatorcontrib><creatorcontrib>García-Castillo, Elena</creatorcontrib><creatorcontrib>Pastor-Sanz, Maria Teresa</creatorcontrib><creatorcontrib>Olveira, Casilda</creatorcontrib><creatorcontrib>García-Clemente, Marta María</creatorcontrib><creatorcontrib>Nieto-Royo, Rosa</creatorcontrib><creatorcontrib>Prados-Sánchez, Concha</creatorcontrib><creatorcontrib>Caballero-Sánchez, Paloma</creatorcontrib><creatorcontrib>Olivera-Serrano, Maria Jose</creatorcontrib><creatorcontrib>Padilla-Galo, Alicia</creatorcontrib><creatorcontrib>Nava-Tomas, Encarnacion</creatorcontrib><creatorcontrib>Esteban-Peris, Amparo</creatorcontrib><creatorcontrib>Fernández-Velilla, Maria</creatorcontrib><creatorcontrib>Torres, Maribel</creatorcontrib><creatorcontrib>Gómez-Punter, Rosa Mar</creatorcontrib><creatorcontrib>Ancochea, Julio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diab-Cáceres, Layla</au><au>Girón-Moreno, Rosa María</au><au>García-Castillo, Elena</au><au>Pastor-Sanz, Maria Teresa</au><au>Olveira, Casilda</au><au>García-Clemente, Marta María</au><au>Nieto-Royo, Rosa</au><au>Prados-Sánchez, Concha</au><au>Caballero-Sánchez, Paloma</au><au>Olivera-Serrano, Maria Jose</au><au>Padilla-Galo, Alicia</au><au>Nava-Tomas, Encarnacion</au><au>Esteban-Peris, Amparo</au><au>Fernández-Velilla, Maria</au><au>Torres, Maribel</au><au>Gómez-Punter, Rosa Mar</au><au>Ancochea, Julio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2021</date><risdate>2021</risdate><volume>31</volume><issue>1</issue><spage>112</spage><epage>120</epage><pages>112-120</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
The objective of this study was to analyze the predictive value of the modified Bhalla score in high-resolution computed tomography (HRCT) for assessment of pulmonary exacerbations (PEx) in cystic fibrosis (CF) patients. We also describe the relationship between this score and pulmonary function test results.
Methods
We performed a multicenter and prospective study where adult patients with CF were included consecutively over 18 months. All patients underwent HRCT with acquisition in inspiration and expiration. The results were analyzed by an expert radiologist who assigned a modified Bhalla score value. Lung function was also assessed, and clinical variables were collected. Follow-up lasted approximately 1 year, and PEx were registered.
Results
The study population comprised 160 subjects selected from 360 CF patients monitored in the participating CF units. The mean age was 28 years, 47.5% were women, and mean forced expiratory volume in 1 s (FEV
1
) was 67.5%. The mean global modified Bhalla score was 14.5 ± 0.31 points. Pulmonary function test (PFT) results and the modified Bhalla score correlated well, mainly forced vital capacity (FVC) and FEV
1
. We constructed a statistical model based on the overall Bhalla score to predict the number of PEx.
Conclusions
The overall modified Bhalla score can predict future PEx in CF patients. This useful tool can help to prevent PEx in higher risk patients.
Key Points
• Pulmonary function test results and the modified Bhalla score correlated well with FVC and FEV
1
.
• The total modified Bhalla score can predict the number of exacerbations in adult CF patients.
• Our findings highlight the need to establish a unified protocol for chest HRCT during the follow-up of adult patients with CF in order to anticipate possible complications and determine their impact on pulmonary function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32740815</pmid><doi>10.1007/s00330-020-07095-y</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2021, Vol.31 (1), p.112-120 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2430101166 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Complications Computed Tomography Correlation analysis Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - diagnostic imaging Diagnostic Radiology Female Forced Expiratory Volume Humans Imaging Internal Medicine Interventional Radiology Lung - diagnostic imaging Male Mathematical models Medicine Medicine & Public Health Neuroradiology Population studies Prospective Studies Pulmonary functions Radiology Respiratory function Statistical models Ultrasound Vital Capacity |
| title | Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis |
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