Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities

Incorporation of water has been revealed to successfully facilitate visible-light photoredox catalysis of indole leading to increased production of C2-quaternary indolinone. The water-promoted photoreaction of indole under catalyst-free conditions by a household compact fluorescence light was also d...

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Veröffentlicht in:	Organic & biomolecular chemistry 2020-08, Vol.18 (32), p.6247-6252
Hauptverfasser:	Cheng, Li-Ting, Luo, Sheng-Qi, Hong, Bor-Cherng, Chen, Chia-Ling, Li, Wen-Shan, Lee, Gene-Hsiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Catalysis Catalysts Cell Line, Tumor Cell Proliferation - drug effects Crystallography Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fluorescence High-performance liquid chromatography Humans Indoles Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Light Liquid chromatography Molecular Structure Oxidation-Reduction Photochemical Processes Photoredox catalysis Quaternary Structure-Activity Relationship Tumor cell lines Water - chemistry
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Zusammenfassung:	Incorporation of water has been revealed to successfully facilitate visible-light photoredox catalysis of indole leading to increased production of C2-quaternary indolinone. The water-promoted photoreaction of indole under catalyst-free conditions by a household compact fluorescence light was also demonstrated. The antiproliferative activity of the synthesized indolinones was evaluated against three human cancer cell lines.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/d0ob01298j