Circulating pregnancy hormone relaxin as a first trimester biomarker for preeclampsia

•Early identification of pregnancies at risk for preeclampsia is a challenge in modern obstetrics.•Circulating relaxin is emerging as an important regulator of maternal vascular adaptations to pregnancy.•Late-onset preeclampsia is associated with low relaxin levels in the 1st trimester of pregnancy....

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Veröffentlicht in:Pregnancy hypertension 2020-10, Vol.22, p.47-53
Hauptverfasser: Post Uiterweer, Emiel D., Koster, Maria P.H., Jeyabalan, Arun, Kuc, Sylwia, Siljee, Jacqueline E., Stewart, Dennis R., Conrad, Kirk P., Franx, Arie
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Sprache:eng
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Zusammenfassung:•Early identification of pregnancies at risk for preeclampsia is a challenge in modern obstetrics.•Circulating relaxin is emerging as an important regulator of maternal vascular adaptations to pregnancy.•Late-onset preeclampsia is associated with low relaxin levels in the 1st trimester of pregnancy.•Particularly late-onset preeclampsia combined with a small for gestational age infant. Preeclampsia, a multi-system hypertensive disorder, is associated with perturbations in the maternal cardiovascular system during early pregnancy. The corpus luteal hormone relaxin, a potent vasodilator, may contribute to physiological circulatory changes especially in early gestation when circulating levels are highest. This study investigated whether first trimester circulating relaxin may be a suitable biomarker for the early prediction of preeclampsia. Relaxin was initially measured in first-trimester samples of women who developed late-onset preeclamptic (LO-PE; delivery ≥ 34 weeks; n = 33) and uncomplicated pregnancies (n = 25) in Pittsburgh, USA. Subsequently, to expand the group numbers, relaxin was measured in women who developed LO-PE (n = 95), early-onset preeclamptic (EO-PE; delivery 
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2020.07.008