Clinical features of anti‐transcription intermediary factor 1γ (TIF1γ)‐positive dermatomyositis with internal malignancy and investigation of the involvement of TIF1γ expression in tumors in the pathogenesis of cancer‐associated dermatomyositis

Anti‐transcription intermediary factor 1γ (anti‐TIF1γ) antibody (Ab) is significantly associated with internal malignancies in adult patients with dermatomyositis (DM). Although pathogenesis of cancer‐associated DM is unknown, TIF1γ overexpression in tumors has been considered to be critical for the development of DM. The objective of this study was to investigate clinical characteristics of patients with anti‐TIF1γ Ab‐positive DM and elucidate risk factors that are potentially associated with internal malignancy. In addition, we compared the expression of TIF1γ in tumor tissues of patients with anti‐TIF1γ Ab‐positive DM, anti‐TIF1γ Ab‐negative DM and without DM in order to investigate the pathogenesis of cancer‐associated DM. We analyzed 77 Japanese patients with DM, and found 19 patients to be positive for anti‐TIF1γ Ab. Patients with anti‐TIF1γ Ab‐positive DM were older and presented heliotrope rash and flagellate erythema more frequently than patients without anti‐TIF1γ Ab (P