Parkinson's disease and pesticides: Are microRNAs the missing link?

Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, and among its pathogenic factors oxidative stress plays a critical role in disease progression. Pesticides are a broad class of chemicals widely used in agriculture and households for the protection of crops from insects and fungi. Several of them have been incriminated as risk factors for PD, but the underlying mechanisms have yet to be fully understood. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in regulating mRNA translation and protein synthesis. miRNA levels have been shown to be affected in several diseases as well. Since the studies on the association between pesticides and PD have yet to reach definitive conclusions, here we review recent evidence on deregulated microRNAs upon pesticide exposure, and attempt to find an overlap between miRNAs deregulated in PD and pesticides, as a missing link between the two, and enhance future research in this direction. [Display omitted] •There are common miRNA links between Parkinson's Disease (PD) and pesticides.•Several pesticide-deregulated miRNAs affect PD-related molecules, e.g. α-synuclein.•Paraquat, Organophosphates and Rotenone continue to inform on PD pathology.•Undesrtanding of pesticide x miRNA interactions remain embryonic.•Future studies need to have consistent designs to allow for meaningful conclusions.