Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats

To explore the effect of intrathecal injection of lycopene on pain facilitation, glial activation, and the SIRT1/mTOR pathway in the dorsal horn of rats with burn injury pain (BIP). Here we found that the mechanical pain threshold increased in the lycopene group compared with that of the control gro...

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Veröffentlicht in:	European journal of pharmacology 2020-12, Vol.889, p.173365-173365, Article 173365
Hauptverfasser:	Yin, Qin, Wang, Jin-Feng, Xu, Xiao-Hua, Xie, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Burn injury pain Burns - drug therapy Burns - metabolism Carbazoles - administration & dosage Glial activation Injections, Spinal - methods Lycopene Lycopene - administration & dosage Male mTOR Pain Threshold - drug effects Pain Threshold - physiology Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology SIRT1 Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - metabolism Spinal Cord Dorsal Horn - drug effects Spinal Cord Dorsal Horn - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Treatment Outcome
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Zusammenfassung:	To explore the effect of intrathecal injection of lycopene on pain facilitation, glial activation, and the SIRT1/mTOR pathway in the dorsal horn of rats with burn injury pain (BIP). Here we found that the mechanical pain threshold increased in the lycopene group compared with that of the control group, (P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/j.ejphar.2020.173365