Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: a multi-institutional study

Background Although the clinicopathological significance of serum p53 antibodies (s-p53-Abs) in esophageal cancer have been evaluated previously, previous reports only analyzed around 100–200 patients. This study was a multi-institutional study promoted by the Japan Esophageal Society to evaluate th...

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Veröffentlicht in:Esophagus : official journal of the Japan Esophageal Society 2021, Vol.18 (1), p.65-71
Hauptverfasser: Takashi, Suzuki, Satoshi, Yajima, Akihiko, Okamura, Naoya, Yoshida, Yusuke, Taniyama, Kentaro, Murakami, Yu, Ohkura, Yasuaki, Nakajima, Koichi, Yagi, Takashi, Fukuda, Ryo, Ogawa, Isamu, Hoshino, Chikara, Kunisaki, Kosuke, Narumiya, Yasuhiro, Tsubosa, Kazuhiko, Yamada, Hideaki, Shimada
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Sprache:eng
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Zusammenfassung:Background Although the clinicopathological significance of serum p53 antibodies (s-p53-Abs) in esophageal cancer have been evaluated previously, previous reports only analyzed around 100–200 patients. This study was a multi-institutional study promoted by the Japan Esophageal Society to evaluate the clinical significance of preoperative s-p53-Ab status and antibody titers in 1487 esophageal cancer patients without neoadjuvant therapy. Methods A total of 1487 patients with esophageal squamous cell carcinoma surgically treated between 2008 and 2016 in 15 hospitals in Japan were enrolled. The cut-off value to classify the patients into s-p53-Ab positive and negative groups was 1.30 U/ml. A receiver operating characteristic curve was constructed to assess the s-p53-Abs cut-off levels to differentiate poor prognosis among the s-p53-Ab positive group. Univariate and multivariate analyses were used to evaluate the clinicopathological and prognostic significance of s-p53-Ab status and titers. Results Although s-p53-Ab status was significantly associated with tumor depth ( P  = 0.002), nodal status ( P  = 0.027), and pathological stage ( P  = 0.002). The s-p53-Ab positive status was not significantly associated with poor overall survival ( P  = 0.699). Using 9.82 U/ml as a cut-off, the high s-p53-Ab titer group showed a significantly worse overall survival than the low s-p53-Ab titer group ( P  = 0.038). However, the difference was not significant in the multivariate analysis. Conclusion The presence of s-p53-Abs was associated with tumor progression. Although high s-p53-Ab titers more than 9.82 U/ml, might be associated with poor prognosis for patients with esophageal squamous cell carcinoma, it was not an independent risk factor.
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-020-00761-6