Expression of microRNA-210 and the prognosis in glioma patients: a meta-analysis

To evaluate the predictive power of tumor microRNA-210 (miR-210) on overall survival (OS) in glioma patients. Studies were identified through searching PubMed, Embase and China National Knowledge Internet electronic databases. Meta-analyses were performed with a random- or fixed-effect model accordi...

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Veröffentlicht in:	Biomarkers in medicine 2020-06, Vol.14 (9), p.795-805
Hauptverfasser:	Hu, Xuezhi, Yan, Pengfei, Feng, Jun, Zhang, Fangcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Asymmetry Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - mortality Classification Datasets Gender Gene expression Gene Expression Regulation, Neoplastic Glioblastoma Glioma Glioma - diagnosis Glioma - genetics Glioma - metabolism Glioma - mortality Glioma - pathology Humans Medical prognosis Meta-analysis microRNA-210 MicroRNAs MicroRNAs - genetics miRNA Pathogenesis Patients Prognosis Survival
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Zusammenfassung:	To evaluate the predictive power of tumor microRNA-210 (miR-210) on overall survival (OS) in glioma patients. Studies were identified through searching PubMed, Embase and China National Knowledge Internet electronic databases. Meta-analyses were performed with a random- or fixed-effect model according to the heterogeneity. Six studies were included. Results showed that increased miR-210 expression in tumor independently predicted poor OS in glioma patients (hazard ratio [HR]: 1.38; p = 0.001). Subgroup analyses showed that the prognostic efficacy of tumor miR-210 levels for OS was stronger in overall patients with glioma (HR: 2.22; p
ISSN:	1752-0363 1752-0371 1752-0371
DOI:	10.2217/bmm-2019-0448