The importance of intracellular bacterial biofilm in infectious diseases

Various bacterial species, previously known as extracellular pathogens, can reside inside different host cells by adapting to intracellular modes by forming microbial aggregates with similar characteristics to bacterial biofilms. Additionally, bacterial invasion of human cells leads to failure in an...

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Veröffentlicht in:Microbial pathogenesis 2020-10, Vol.147, p.104393-104393, Article 104393
Hauptverfasser: Mirzaei, Rasoul, Mohammadzadeh, Rokhsareh, Sholeh, Mohammad, Karampoor, Sajad, Abdi, Milad, Dogan, Eyup, Moghadam, Mohammad Shokri, Kazemi, Sima, Jalalifar, Saba, Dalir, Amine, Yousefimashouf, Rasoul, Mirzaei, Ebrahim, Khodavirdipour, Amir, Alikhani, Mohammad Yousef
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Sprache:eng
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Zusammenfassung:Various bacterial species, previously known as extracellular pathogens, can reside inside different host cells by adapting to intracellular modes by forming microbial aggregates with similar characteristics to bacterial biofilms. Additionally, bacterial invasion of human cells leads to failure in antibiotic therapy, as most conventional anti-bacterial agents cannot reach intracellular biofilm in normal concentrations. Various studies have shown that bacteria such as uropathogenic Escherichia coli, Pseudomonas aeruginosa, Borrelia burgdorferi,Moraxella catarrhalis, non-typeable Haemophilus influenzae, Streptococcus pneumonia, and group A Streptococci produce biofilm-like structures within the host cells. For the first time in this review, we will describe and discuss the new information about intracellular bacterial biofilm formation and its importance in bacterial infectious diseases. •Biofilms are structured microbial aggregates attached to biotic or abiotic surfaces that have been extensively studied in recent years as they are involved in chronic bacterial infections.•Biofilm, as a fixing framework, consists of EPS and various carbohydrate-binding bacterial proteins and eDNA.•The EPS structure alters in response to variations in the availability of various micro-nutrient and the secretion of specific enzymes from bacterial cells; therefore, bacterial cells within the biofilm structure can become compatible with certain environments.•Many studies have shown that bacteria, including uropathogenic E. coli, P. aeruginosa, B. burgdorferi, M. catarrhalis, non-typeable H. influenza (NTHI), S. pneumoniae, and group A Streptococci may produce biofilm-like structures inside the host cells.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2020.104393