Carotid and cerebrovascular dual-energy computed tomography angiography: Optimization of window settings for virtual monoenergetic imaging reconstruction
•Virtual monoenergetic images (VMI) can be calculated from dual-energy CT angiography (DE-CTA).•VMI reconstructions can drastically improve vessel contrast, but require dedicated windowing.•Both subjectively best (B–W/L) and objectively best (O–W/L) window settings were assessed.•Ideal window settin...
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| Veröffentlicht in: | European journal of radiology 2020-09, Vol.130, p.109166-109166, Article 109166 |
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| creator | D'Angelo, Tommaso Lenga, Lukas Arendt, Christophe T. Bucher, Andreas M. Peterke, Julia L. Caruso, Damiano Mazziotti, Silvio Ascenti, Giorgio Blandino, Alfredo Othman, Ahmed E. Martin, Simon S. Albrecht, Moritz H. Bodelle, Boris Vogl, Thomas J. Wichmann, Julian L. |
| description | •Virtual monoenergetic images (VMI) can be calculated from dual-energy CT angiography (DE-CTA).•VMI reconstructions can drastically improve vessel contrast, but require dedicated windowing.•Both subjectively best (B–W/L) and objectively best (O–W/L) window settings were assessed.•Ideal window settings for VMI and novel VMI + were significantly higher than for standard DE-CTA.•Readers subjectively prefered M40+ reconstructions regarding overall image quality.
Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA.
Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard linearly-blended (M_0.6), 70-keV traditional VMI (M70), and 40-keV noise-optimized VMI (M40+) reconstructions were analyzed. For M70 and M40+ datasets, the subjectively best window setting (width and level, B–W/L) was independently determined by two observers and subsequently related with aortic arch attenuation to calculate optimized values (O–W/L) using linear regression. Subjective evaluation of image quality (IQ) between W/L settings were assessed by two additional readers. Repeated measures analysis of variance were performed to compare W/L settings and IQ indices between M_0.6, M70, and M40 + .
B–W/L and O–W/L for M70 were 580/210 and 560/200, and for M40+ were 1630/570 and 1560/550, respectively, higher than standard DE-CTA W/L settings (450/100). Highest subjective scores were observed for M40+ regarding overall IQ (all p |
| doi_str_mv | 10.1016/j.ejrad.2020.109166 |
| format | Article |
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Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA.
Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard linearly-blended (M_0.6), 70-keV traditional VMI (M70), and 40-keV noise-optimized VMI (M40+) reconstructions were analyzed. For M70 and M40+ datasets, the subjectively best window setting (width and level, B–W/L) was independently determined by two observers and subsequently related with aortic arch attenuation to calculate optimized values (O–W/L) using linear regression. Subjective evaluation of image quality (IQ) between W/L settings were assessed by two additional readers. Repeated measures analysis of variance were performed to compare W/L settings and IQ indices between M_0.6, M70, and M40 + .
B–W/L and O–W/L for M70 were 580/210 and 560/200, and for M40+ were 1630/570 and 1560/550, respectively, higher than standard DE-CTA W/L settings (450/100). Highest subjective scores were observed for M40+ regarding overall IQ (all p < 0.001).
Application of O–W/L settings is mandatory to optimize subjective IQ of VMI reconstructions of DE-CTA.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2020.109166</identifier><identifier>PMID: 32693314</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - diagnostic imaging ; Carotid disease ; Cerebrovascular Disorders - diagnostic imaging ; Computed tomography ; Computed tomography angiography ; Computed Tomography Angiography - methods ; Dual-energy ; Female ; Humans ; Image postprocessing ; Male ; Middle Aged ; Radiographic Image Interpretation, Computer-Assisted - methods ; Radiography, Dual-Energy Scanned Projection - methods ; Reproducibility of Results ; Retrospective Studies ; Signal-To-Noise Ratio</subject><ispartof>European journal of radiology, 2020-09, Vol.130, p.109166-109166, Article 109166</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-b30e0ac418f8c32984bd04d556843ad82bd3ed00fec5d054b98b75d62b06ce1f3</citedby><cites>FETCH-LOGICAL-c425t-b30e0ac418f8c32984bd04d556843ad82bd3ed00fec5d054b98b75d62b06ce1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0720048X20303557$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32693314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Angelo, Tommaso</creatorcontrib><creatorcontrib>Lenga, Lukas</creatorcontrib><creatorcontrib>Arendt, Christophe T.</creatorcontrib><creatorcontrib>Bucher, Andreas M.</creatorcontrib><creatorcontrib>Peterke, Julia L.</creatorcontrib><creatorcontrib>Caruso, Damiano</creatorcontrib><creatorcontrib>Mazziotti, Silvio</creatorcontrib><creatorcontrib>Ascenti, Giorgio</creatorcontrib><creatorcontrib>Blandino, Alfredo</creatorcontrib><creatorcontrib>Othman, Ahmed E.</creatorcontrib><creatorcontrib>Martin, Simon S.</creatorcontrib><creatorcontrib>Albrecht, Moritz H.</creatorcontrib><creatorcontrib>Bodelle, Boris</creatorcontrib><creatorcontrib>Vogl, Thomas J.</creatorcontrib><creatorcontrib>Wichmann, Julian L.</creatorcontrib><title>Carotid and cerebrovascular dual-energy computed tomography angiography: Optimization of window settings for virtual monoenergetic imaging reconstruction</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>•Virtual monoenergetic images (VMI) can be calculated from dual-energy CT angiography (DE-CTA).•VMI reconstructions can drastically improve vessel contrast, but require dedicated windowing.•Both subjectively best (B–W/L) and objectively best (O–W/L) window settings were assessed.•Ideal window settings for VMI and novel VMI + were significantly higher than for standard DE-CTA.•Readers subjectively prefered M40+ reconstructions regarding overall image quality.
Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA.
Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard linearly-blended (M_0.6), 70-keV traditional VMI (M70), and 40-keV noise-optimized VMI (M40+) reconstructions were analyzed. For M70 and M40+ datasets, the subjectively best window setting (width and level, B–W/L) was independently determined by two observers and subsequently related with aortic arch attenuation to calculate optimized values (O–W/L) using linear regression. Subjective evaluation of image quality (IQ) between W/L settings were assessed by two additional readers. Repeated measures analysis of variance were performed to compare W/L settings and IQ indices between M_0.6, M70, and M40 + .
B–W/L and O–W/L for M70 were 580/210 and 560/200, and for M40+ were 1630/570 and 1560/550, respectively, higher than standard DE-CTA W/L settings (450/100). Highest subjective scores were observed for M40+ regarding overall IQ (all p < 0.001).
Application of O–W/L settings is mandatory to optimize subjective IQ of VMI reconstructions of DE-CTA.</description><subject>Aged</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid disease</subject><subject>Cerebrovascular Disorders - diagnostic imaging</subject><subject>Computed tomography</subject><subject>Computed tomography angiography</subject><subject>Computed Tomography Angiography - methods</subject><subject>Dual-energy</subject><subject>Female</subject><subject>Humans</subject><subject>Image postprocessing</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiographic Image Interpretation, Computer-Assisted - methods</subject><subject>Radiography, Dual-Energy Scanned Projection - methods</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Signal-To-Noise Ratio</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAUhS0EYjoDT4CEvGST4r8kDhILVAGDNNJsQGJnOfZNcJXYwXY6Km_C2-JOC0tWvrK-c-7PQegVJVtKaPN2v4V91HbLCDv9dLRpnqANlS2r2pa1T9GGtIxURMjvV-g6pT0hpBYde46uOGs6zqnYoN87HUN2FmtvsYEIfQwHncw66YjtqqcKPMTxiE2YlzWDxTnMYYx6-XEsmtFd6nf4fsludr90dsHjMOAH5214wAlydn5MeAgRH1zMxRPPwYdHX8jOYDfrsSA4ggk-5biak8cL9GzQU4KXl_cGffv08evutrq7__xl9-GuMoLVueo5AaKNoHKQhrNOit4SYeu6kYJrK1lvOVhCBjC1Lfv3nezb2jasJ40BOvAb9Obsu8Twc4WU1eySgWnSHsKaFBOsoW1HZVdQfkZNDClFGNQSy_DxqChRp0zUXj1mok6ZqHMmRfX60mDtZ7D_NH9DKMD7MwBlzYODqJJx4A1YV06SlQ3uvw3-AOd0o8A</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>D'Angelo, Tommaso</creator><creator>Lenga, Lukas</creator><creator>Arendt, Christophe T.</creator><creator>Bucher, Andreas M.</creator><creator>Peterke, Julia L.</creator><creator>Caruso, Damiano</creator><creator>Mazziotti, Silvio</creator><creator>Ascenti, Giorgio</creator><creator>Blandino, Alfredo</creator><creator>Othman, Ahmed E.</creator><creator>Martin, Simon S.</creator><creator>Albrecht, Moritz H.</creator><creator>Bodelle, Boris</creator><creator>Vogl, Thomas J.</creator><creator>Wichmann, Julian L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Carotid and cerebrovascular dual-energy computed tomography angiography: Optimization of window settings for virtual monoenergetic imaging reconstruction</title><author>D'Angelo, Tommaso ; 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Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA.
Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard linearly-blended (M_0.6), 70-keV traditional VMI (M70), and 40-keV noise-optimized VMI (M40+) reconstructions were analyzed. For M70 and M40+ datasets, the subjectively best window setting (width and level, B–W/L) was independently determined by two observers and subsequently related with aortic arch attenuation to calculate optimized values (O–W/L) using linear regression. Subjective evaluation of image quality (IQ) between W/L settings were assessed by two additional readers. Repeated measures analysis of variance were performed to compare W/L settings and IQ indices between M_0.6, M70, and M40 + .
B–W/L and O–W/L for M70 were 580/210 and 560/200, and for M40+ were 1630/570 and 1560/550, respectively, higher than standard DE-CTA W/L settings (450/100). Highest subjective scores were observed for M40+ regarding overall IQ (all p < 0.001).
Application of O–W/L settings is mandatory to optimize subjective IQ of VMI reconstructions of DE-CTA.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32693314</pmid><doi>10.1016/j.ejrad.2020.109166</doi><tpages>1</tpages></addata></record> |
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| subjects | Aged Carotid Arteries - diagnostic imaging Carotid Artery Diseases - diagnostic imaging Carotid disease Cerebrovascular Disorders - diagnostic imaging Computed tomography Computed tomography angiography Computed Tomography Angiography - methods Dual-energy Female Humans Image postprocessing Male Middle Aged Radiographic Image Interpretation, Computer-Assisted - methods Radiography, Dual-Energy Scanned Projection - methods Reproducibility of Results Retrospective Studies Signal-To-Noise Ratio |
| title | Carotid and cerebrovascular dual-energy computed tomography angiography: Optimization of window settings for virtual monoenergetic imaging reconstruction |
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