Dexamethasone in Hospitalized Patients with Covid-19

Among hospitalized patients with Covid-19, treatment with dexamethasone resulted in lower 28-day mortality than usual care, according to the level of respiratory support the patients were receiving, indicating a possible correlation between efficacy and the stage of infection.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-02, Vol.384 (8), p.693-704
Hauptverfasser:	Horby, Peter, Lim, Wei Shen, Emberson, Jonathan R, Mafham, Marion, Bell, Jennifer L, Linsell, Louise, Staplin, Natalie, Brightling, Christopher, Ustianowski, Andrew, Elmahi, Einas, Prudon, Benjamin, Green, Christopher, Felton, Timothy, Chadwick, David, Rege, Kanchan, Fegan, Christopher, Chappell, Lucy C, Faust, Saul N, Jaki, Thomas, Jeffery, Katie, Montgomery, Alan, Rowan, Kathryn, Juszczak, Edmund, Baillie, J Kenneth, Haynes, Richard, Landray, Martin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Aged, 80 and over Anti-Infective Agents - therapeutic use Coronaviruses COVID-19 COVID-19 - mortality COVID-19 - therapy COVID-19 Drug Treatment Dexamethasone Dexamethasone - administration & dosage Dexamethasone - adverse effects Dexamethasone - therapeutic use Drug Therapy, Combination Fatalities Female Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Hospitalization Humans Inflammation Injections, Intravenous Intravenous administration Kaplan-Meier Estimate Length of Stay Male Mechanical ventilation Medical research Mortality Odds Ratio Oxygen Oxygen Inhalation Therapy Respiration, Artificial Respiratory failure Steroids United Kingdom
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Beschreibung
Zusammenfassung:	Among hospitalized patients with Covid-19, treatment with dexamethasone resulted in lower 28-day mortality than usual care, according to the level of respiratory support the patients were receiving, indicating a possible correlation between efficacy and the stage of infection.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2021436