Multiple endocrine neoplasia type 1 revealed by a hip pathologic fracture

Multiple endocrine neoplasia type 1 is a rare autosomal inherited syndrome that affects a variety of endocrine tissues such as the parathyroid, endocrine pancreas, and anterior pituitary. Osseous complications are often misdiagnosed. We presented a case of a 46-year-old woman with pathological fract...

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Veröffentlicht in:Clinical rheumatology 2021-02, Vol.40 (2), p.775-782
Hauptverfasser: Slouma, Maroua, Abbes, Maissa, Dhahri, Rim, Litaiem, Noureddine, Gueddiche, Nour, Mansouri, Nada, Msekni, Issam, Gharsallah, Imen, Metoui, Leila, Louzir, Bassem
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Sprache:eng
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Zusammenfassung:Multiple endocrine neoplasia type 1 is a rare autosomal inherited syndrome that affects a variety of endocrine tissues such as the parathyroid, endocrine pancreas, and anterior pituitary. Osseous complications are often misdiagnosed. We presented a case of a 46-year-old woman with pathological fractures of the lower limb. She had a history of type 1 diabetes and galactorrhea. Laboratory examinations showed hypercalcemia and an increased level of parathyroid hormone related to hyperparathyroidism. Serum chromogranin A level was increased at 9369 ng/mL ( N  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-020-05281-3