Epidural/spinal anesthesia during delivery in women with factor XI deficiency, a single center experience

Introduction The safety of neuro‐axial anaesthesia (epidural/spinal) at labour of women with partial factor XI (FXI) deficiency is uncertain. Although FXI deficiency is frequent in Ashkenazi Jews, it is not routinely measured before labour. Our institute serves a large Ashkenazi population. We assum...

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Veröffentlicht in:Haemophilia : the official journal of the World Federation of Hemophilia 2020-09, Vol.26 (5), p.834-839
Hauptverfasser: Shacham Abulafia, Adi, Yaniv, Yuval, Steimatzky, Arza, Orbach‐Zinger, Sharon, Hadar, Eran, Shmueli, Anat, Borovich, Adi, Ziv, Ester, Rozovski, Uri, Wiznitzer, Arnon, Eidelman, Leonid A., Raanani, Pia, Spectre, Galia
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Sprache:eng
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Zusammenfassung:Introduction The safety of neuro‐axial anaesthesia (epidural/spinal) at labour of women with partial factor XI (FXI) deficiency is uncertain. Although FXI deficiency is frequent in Ashkenazi Jews, it is not routinely measured before labour. Our institute serves a large Ashkenazi population. We assumed that 10% of them have undiagnosed FXI deficiency. Aim Assess the incidence, bleeding tendency and coagulation status among Jewish Ashkenazi women with FXI deficiency that underwent neuro‐axial anaesthesia at delivery. Methods Jewish Ashkenazi women who underwent neuro‐axial anaesthesia at labour completed the SSC ISTH bleeding assessment tool (BAT) and had blood drawn for coagulation tests, FXI and thrombin generation after labour. Estimation for 10 years was calculated from the 1‐year sample. Results We recruited 261 women during 12 months. Among them, 39 (15%) had FXI deficiency (
ISSN:1351-8216
1365-2516
DOI:10.1111/hae.14079