Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD). Despite a similar incidence of heart failure in men and women, prior studies have hi...
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| Veröffentlicht in: | JACC. Heart failure 2020-09, Vol.8 (9), p.770-779 |
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| container_title | JACC. Heart failure |
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| creator | Gruen, Jadry Caraballo, Cesar Miller, P. Elliott McCullough, Megan Mezzacappa, Catherine Ravindra, Neal Mullan, Clancy W. Reinhardt, Samuel W. Mori, Makoto Velazquez, Eric Geirsson, Arnar Ahmad, Tariq Desai, Nihar R. |
| description | This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD).
Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in women, and studies of clinical outcomes have yielded conflicting results.
Patients were enrolled from the INTERMACS study who underwent implantation of their first continuous-flow LVAD between 2008 and 2017, and survival analyses stratified by sex were conducted.
Among the 18,868 patients, 3,984 (21.1%) were women. At 1 year, women were less likely to undergo heart transplantation than men (17.9% vs. 20.0%, respectively; p = 0.003). After multivariable adjustments, women had a higher risk of death (hazard ratio [HR]: 1.15; 95% confidence interval [CI]: 1.07 to 1.23; p |
| doi_str_mv | 10.1016/j.jchf.2020.04.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2423516969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2213177920302705</els_id><sourcerecordid>2423516969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-74c630aa3da742437cea5354138d06ae911d36363b576177ff7f64b0ae2c333a3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EAgT8AAvkJZsEv-KkEpuKV5EqgXhtLdcZg6s0KbZTwd_wLXwZjlpYMrOY0ejeK81B6JiSnBIqz-b53LzZnBFGciJyQosttM8Y5Rktq3L7by9He-gohDlJVRW0qqpdtMeZLLgQch_NHuEDXzprwUNrIGDX4nsdHbQx4Acw4FaufcVTsBG_pKN3pm-0x-MQXIj4ElZucNnO46u2zh6jfgU8Ae3j99e1dk3v4RDtWN0EONrMA_R8ffV0Mcmmdze3F-NpZnghY1YKIznRmte6FEzw0oAueCEor2oiNYworblMPStKmf6ytrRSzIgGZjjnmh-g03Xu0nfvPYSoFi4YaBrdQtcHxQTjBZUjOUpStpYa34XgwaqldwvtPxUlasCr5mrAqwa8igiV8CbTySa_ny2g_rP8wkyC87UA0pcrB14F4waqtfNgoqo791_-D_1wiys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2423516969</pqid></control><display><type>article</type><title>Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Gruen, Jadry ; Caraballo, Cesar ; Miller, P. Elliott ; McCullough, Megan ; Mezzacappa, Catherine ; Ravindra, Neal ; Mullan, Clancy W. ; Reinhardt, Samuel W. ; Mori, Makoto ; Velazquez, Eric ; Geirsson, Arnar ; Ahmad, Tariq ; Desai, Nihar R.</creator><creatorcontrib>Gruen, Jadry ; Caraballo, Cesar ; Miller, P. Elliott ; McCullough, Megan ; Mezzacappa, Catherine ; Ravindra, Neal ; Mullan, Clancy W. ; Reinhardt, Samuel W. ; Mori, Makoto ; Velazquez, Eric ; Geirsson, Arnar ; Ahmad, Tariq ; Desai, Nihar R.</creatorcontrib><description>This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD).
Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in women, and studies of clinical outcomes have yielded conflicting results.
Patients were enrolled from the INTERMACS study who underwent implantation of their first continuous-flow LVAD between 2008 and 2017, and survival analyses stratified by sex were conducted.
Among the 18,868 patients, 3,984 (21.1%) were women. At 1 year, women were less likely to undergo heart transplantation than men (17.9% vs. 20.0%, respectively; p = 0.003). After multivariable adjustments, women had a higher risk of death (hazard ratio [HR]: 1.15; 95% confidence interval [CI]: 1.07 to 1.23; p < 0.001) and were more likely to incur post-implantation adverse events, including rehospitalization, bleeding, stroke, and pump thrombosis or device malfunction. Although women younger than 50 years of age had an increased risk of death compared to men of the same age (HR: 1.34; 95% CI: 1.12 to 1.6), men and women 65 years of age and older had a similar risk of death (HR: 1.09; 95% CI: 0.95 to 1.24).
This study found that women had a higher risk of mortality and adverse events after LVAD. Only 1 in 5 LVADs were implanted in women, and women were less likely to receive a heart transplant than men. Further investigation is needed to understand the causes of adverse events and potential underuse of advanced treatment options in women.
[Display omitted]</description><identifier>ISSN: 2213-1779</identifier><identifier>EISSN: 2213-1787</identifier><identifier>DOI: 10.1016/j.jchf.2020.04.015</identifier><identifier>PMID: 32653446</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>age ; heart transplant ; INTERMACS ; sex</subject><ispartof>JACC. Heart failure, 2020-09, Vol.8 (9), p.770-779</ispartof><rights>2020 American College of Cardiology Foundation</rights><rights>Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-74c630aa3da742437cea5354138d06ae911d36363b576177ff7f64b0ae2c333a3</citedby><cites>FETCH-LOGICAL-c356t-74c630aa3da742437cea5354138d06ae911d36363b576177ff7f64b0ae2c333a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32653446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruen, Jadry</creatorcontrib><creatorcontrib>Caraballo, Cesar</creatorcontrib><creatorcontrib>Miller, P. Elliott</creatorcontrib><creatorcontrib>McCullough, Megan</creatorcontrib><creatorcontrib>Mezzacappa, Catherine</creatorcontrib><creatorcontrib>Ravindra, Neal</creatorcontrib><creatorcontrib>Mullan, Clancy W.</creatorcontrib><creatorcontrib>Reinhardt, Samuel W.</creatorcontrib><creatorcontrib>Mori, Makoto</creatorcontrib><creatorcontrib>Velazquez, Eric</creatorcontrib><creatorcontrib>Geirsson, Arnar</creatorcontrib><creatorcontrib>Ahmad, Tariq</creatorcontrib><creatorcontrib>Desai, Nihar R.</creatorcontrib><title>Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure</title><title>JACC. Heart failure</title><addtitle>JACC Heart Fail</addtitle><description>This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD).
Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in women, and studies of clinical outcomes have yielded conflicting results.
Patients were enrolled from the INTERMACS study who underwent implantation of their first continuous-flow LVAD between 2008 and 2017, and survival analyses stratified by sex were conducted.
Among the 18,868 patients, 3,984 (21.1%) were women. At 1 year, women were less likely to undergo heart transplantation than men (17.9% vs. 20.0%, respectively; p = 0.003). After multivariable adjustments, women had a higher risk of death (hazard ratio [HR]: 1.15; 95% confidence interval [CI]: 1.07 to 1.23; p < 0.001) and were more likely to incur post-implantation adverse events, including rehospitalization, bleeding, stroke, and pump thrombosis or device malfunction. Although women younger than 50 years of age had an increased risk of death compared to men of the same age (HR: 1.34; 95% CI: 1.12 to 1.6), men and women 65 years of age and older had a similar risk of death (HR: 1.09; 95% CI: 0.95 to 1.24).
This study found that women had a higher risk of mortality and adverse events after LVAD. Only 1 in 5 LVADs were implanted in women, and women were less likely to receive a heart transplant than men. Further investigation is needed to understand the causes of adverse events and potential underuse of advanced treatment options in women.
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Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in women, and studies of clinical outcomes have yielded conflicting results.
Patients were enrolled from the INTERMACS study who underwent implantation of their first continuous-flow LVAD between 2008 and 2017, and survival analyses stratified by sex were conducted.
Among the 18,868 patients, 3,984 (21.1%) were women. At 1 year, women were less likely to undergo heart transplantation than men (17.9% vs. 20.0%, respectively; p = 0.003). After multivariable adjustments, women had a higher risk of death (hazard ratio [HR]: 1.15; 95% confidence interval [CI]: 1.07 to 1.23; p < 0.001) and were more likely to incur post-implantation adverse events, including rehospitalization, bleeding, stroke, and pump thrombosis or device malfunction. Although women younger than 50 years of age had an increased risk of death compared to men of the same age (HR: 1.34; 95% CI: 1.12 to 1.6), men and women 65 years of age and older had a similar risk of death (HR: 1.09; 95% CI: 0.95 to 1.24).
This study found that women had a higher risk of mortality and adverse events after LVAD. Only 1 in 5 LVADs were implanted in women, and women were less likely to receive a heart transplant than men. Further investigation is needed to understand the causes of adverse events and potential underuse of advanced treatment options in women.
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| subjects | age heart transplant INTERMACS sex |
| title | Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure |
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