Intramolecularly stapled amphipathic peptides via a boron-sugar interaction

Intramolecularly stapled amphipathic peptides via a boron-sugar interaction

Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated into various positions of the peptide chain were investigated...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (62), p.8814-8817
Hauptverfasser: Kijewska, Monika, Czerwińska, Angelika, Al-Harthi, Samah, Wołczański, Grzegorz, Waliczek, Mateusz, Emwas, Abdul-Hamid, Jaremko, Mariusz, Jaremko, Łukasz, Stefanowicz, Piotr, Szewczuk, Zbigniew
Format: Artikel
Sprache:eng
Schlagworte:
Boron
Boron - chemistry
Chemical synthesis
Dichroism
Hydrophobic and Hydrophilic Interactions
Mass spectrometry
Models, Molecular
NMR
Nuclear magnetic resonance
Peptides
Peptides - chemistry
Protein Conformation
Sugars - chemistry
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Zusammenfassung:Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated into various positions of the peptide chain were investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc02603d