Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon‐like peptide‐1 receptor agonists: a systematic literature review and indirect treatment comparison

Aims To estimate the relative treatment effect between the fixed‐ratio combinations iGlarLixi and IDegLira (glucagon‐like peptide 1 receptor agonist with basal insulin) in people with type 2 diabetes inadequately controlled on a glucagon‐like peptide 1 receptor agonist. Materials and Methods A syste...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2020-11, Vol.22 (11), p.2170-2178
Hauptverfasser:	Home, Philip D., Aroda, Vanita R., Blonde, Lawrence, Guyot, Patricia, Shaunik, Alka, Fazeli, Mir Sohail, Goswami, Hardik, Kalra, Sanjay, Pourrahmat, Mir‐Masoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Blood glucose Body weight Clinical trials Diabetes Diabetes mellitus (non-insulin dependent) Fasting fixed‐ratio combination GLP-1 receptor agonists Glucagon glucagon‐like peptide‐1 receptor agonist Glucose Hemoglobin hypoglycaemia Hypoglycemia indirect treatment comparison Insulin Literature reviews Peptides Plasma Systematic review Titration
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Zusammenfassung:	Aims To estimate the relative treatment effect between the fixed‐ratio combinations iGlarLixi and IDegLira (glucagon‐like peptide 1 receptor agonist with basal insulin) in people with type 2 diabetes inadequately controlled on a glucagon‐like peptide 1 receptor agonist. Materials and Methods A systematic literature review of randomized controlled trials followed by an indirect treatment comparison was performed to compare the efficacy and safety of the available fixed‐ratio combinations. Main outcomes were glycated haemoglobin (HbA1c) change and target achievement [
ISSN:	1462-8902 1463-1326
DOI:	10.1111/dom.14136