Use of phospholipase C zeta analysis to identify candidates for artificial oocyte activation: a case series of clinical pregnancies and a proposed algorithm for patient management

To investigate the applicability of phospholipase C zeta (PLCζ) analysis in assisting the clinical decision-making process when considering artificial oocyte activation (AOA) for infertile males in assisted reproductive technology. Fifty-six males (43 infertile/13 fertile) were screened using our PL...

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Veröffentlicht in:	Fertility and sterility 2020-07, Vol.114 (1), p.163-174
Hauptverfasser:	Meng, Xin, Melo, Pedro, Jones, Celine, Ross, Caroline, Mounce, Ginny, Turner, Karen, Child, Tim, Coward, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Artificial oocyte activation Biomarkers - analysis calcium ionophore Case-Control Studies Clinical Decision-Making Decision Support Techniques Embryo Transfer Female Fertility Humans Infertility, Male - diagnosis Infertility, Male - enzymology Infertility, Male - physiopathology Infertility, Male - therapy Male oocyte activation deficiency Oocyte Retrieval Oocytes - physiology Ovulation Induction Phosphoinositide Phospholipase C - analysis phospholipase C zeta and PLCζ deficiency Pregnancy Pregnancy Rate Sperm Injections, Intracytoplasmic - adverse effects Spermatozoa - enzymology Treatment Outcome
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Zusammenfassung:	To investigate the applicability of phospholipase C zeta (PLCζ) analysis in assisting the clinical decision-making process when considering artificial oocyte activation (AOA) for infertile males in assisted reproductive technology. Fifty-six males (43 infertile/13 fertile) were screened using our PLCζ assay. Fertility unit/university laboratory. Infertile males with abnormal sperm morphology or total fertilization failure, low fertilization rate (
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2020.02.113