Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

This report describes the epidemiology and clinical course of patients younger than 21 years of age from 26 states who had multisystem inflammatory syndrome. Many were infected with SARS-CoV-2 at least 1 to 2 weeks before syndrome onset. The median age of the patients was 8.3 years, and 73% were pre...

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Veröffentlicht in:	The New England journal of medicine 2020-07, Vol.383 (4), p.334-346
Hauptverfasser:	Feldstein, Leora R, Rose, Erica B, Horwitz, Steven M, Collins, Jennifer P, Newhams, Margaret M, Son, Mary Beth F, Newburger, Jane W, Kleinman, Lawrence C, Heidemann, Sabrina M, Martin, Amarilis A, Singh, Aalok R, Li, Simon, Tarquinio, Keiko M, Jaggi, Preeti, Oster, Matthew E, Zackai, Sheemon P, Gillen, Jennifer, Ratner, Adam J, Walsh, Rowan F, Fitzgerald, Julie C, Keenaghan, Michael A, Alharash, Hussam, Doymaz, Sule, Clouser, Katharine N, Giuliano, John S, Gupta, Anjali, Parker, Robert M, Maddux, Aline B, Havalad, Vinod, Ramsingh, Stacy, Bukulmez, Hulya, Bradford, Tamara T, Smith, Lincoln S, Tenforde, Mark W, Carroll, Christopher L, Riggs, Becky J, Gertz, Shira J, Daube, Ariel, Lansell, Amanda, Coronado Munoz, Alvaro, Hobbs, Charlotte V, Marohn, Kimberly L, Halasa, Natasha B, Patel, Manish M, Randolph, Adrienne G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Betacoronavirus Centers for Disease Control and Prevention, U.S Child Children Coronaviridae Coronavirus Infections - complications Coronavirus Infections - epidemiology Coronavirus Infections - therapy Coronaviruses COVID-19 Critical Care Epidemiology Female Fever Globulins Glucocorticoids Glucocorticoids - therapeutic use Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunomodulation Inflammation Interleukin 6 Intravenous administration Length of Stay Male Mechanical ventilation Mucocutaneous Lymph Node Syndrome - epidemiology Mucocutaneous Lymph Node Syndrome - therapy Mucocutaneous Lymph Node Syndrome - virology Multisystem inflammatory syndrome in children Pandemics Patients Pediatrics Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Pneumonia, Viral - therapy Polymerase chain reaction Prospective Studies Public health Respiration, Artificial Retrospective Studies SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Systemic Inflammatory Response Syndrome - epidemiology Systemic Inflammatory Response Syndrome - therapy Systemic Inflammatory Response Syndrome - virology Teenagers United States Vasoactive agents
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Beschreibung
Zusammenfassung:	This report describes the epidemiology and clinical course of patients younger than 21 years of age from 26 states who had multisystem inflammatory syndrome. Many were infected with SARS-CoV-2 at least 1 to 2 weeks before syndrome onset. The median age of the patients was 8.3 years, and 73% were previously healthy.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2021680