The prevalence of silent acromegaly in prolactinomas is very low
Purpose The aim of this study was to evaluate the somatotroph axis in a large series of patients with prolactinoma to verify the prevalence of silent acromegaly in this population. Methods A hundred and forty-four patients were enrolled in a multicenter study: 90 were already on cabergoline (CAB) an...
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Veröffentlicht in: | Journal of endocrinological investigation 2021-03, Vol.44 (3), p.531-539 |
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Sprache: | eng |
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Zusammenfassung: | Purpose
The aim of this study was to evaluate the somatotroph axis in a large series of patients with prolactinoma to verify the prevalence of silent acromegaly in this population.
Methods
A hundred and forty-four patients were enrolled in a multicenter study: 90 were already on cabergoline (CAB) and enrolled in a cross-sectional arm (group A) with random PRL, GH and IGF-I determination on treatment (≥ 3 months), whereas 54 untreated patients were enrolled at diagnosis in a prospective arm (group B) with PRL, GH and IGF-I measurement before and after 6 and 12 months of treatment. In the presence of high IGF-I, CAB was withdrawn for 3 months and GH, IGF-I, PRL and GH during an oral Glucose Tolerance Test (OGTT) were obtained.
Results
High IGF-I levels (ULN 1.01–1.56) were observed in 9 patients (6.25%, 5F). After CAB withdrawal, IGF-I levels normalized in 5/9 patients, GH was |
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ISSN: | 1720-8386 0391-4097 1720-8386 |
DOI: | 10.1007/s40618-020-01338-x |