Effects of tissue-specific GH receptor knockouts in mice

Growth hormone (GH) is pituitary derived hormone which acts on most tissues of the body either directly or indirectly and affects many metabolic processes throughout life. Genetically engineered mouse lines have become vital tools for uncovering the various in vivo activities of a GH. A particularly useful mouse line has been the GH receptor (GHR) gene disrupted or knockout (KO) mouse which has been used world-wide in many studies. Recent advances in biotechnology have allowed the development of tissue-specific knockout mouse lines which allows for more direct enquiries on the activities of a given protein in specific tissues or cell types. Accordingly, twenty-two novel tissue-specific GHRKO mouse lines have been developed in the last eleven years. In this paper we provide a detailed list and review the phenotypic changes that occur in each of these tissue-specific GHRKO mouse lines. •Disruption of GHR in muscle enhances insulin sensitivity and extends lifespan.•Induced disruption of GHR in adult mice extends lifespan.•GHR regulates weight loss in AgRP neurons.•GHR helps maintain glucose homeostasis in LepRb neurons.•GHR affects pancreatic beta cells ability to stimulate insulin.