Discovering Nature’s super glue

Discovering Nature’s super glue

Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature chemical biology 2020-11, Vol.16 (11), p.1155-1156
Hauptverfasser: Zeng, Zhi, Han, Ting
Format: Artikel
Sprache:eng
Schlagworte:
631/67
631/92/349
631/92/475
631/92/555
Adhesives
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Glues
News & Views
news-and-views
p53 Protein
Polyenes
Polyketides
Polyunsaturated Alkamides
Protein interaction
Proteins
Tumor Suppressor Protein p53
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-020-0586-x