Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome

Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2020-08, Vol.27 (8), p.685-686
Hauptverfasser:	Lim, Patrick S. L., Meshorer, Eran
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2444 631/208/176 631/337/100 631/532/2064 Biochemistry Biological Microscopy Biomedical and Life Sciences Cell lineage Chromatin Deoxyribonucleic acid DNA DNA methylation Embryo cells Embryogenesis Embryonic development Embryonic stem cells Epigenetic inheritance Genetic aspects Genetic research Life Sciences Membrane Biology Methylation News & Views news-and-views Pluripotency Protein Structure Stem cell transplantation Stem cells Structure
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Beschreibung
Zusammenfassung:	Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-020-0453-1