Difference in BPA uptake between glioma stem-like cells and their cancerous cells

Tumor sphere-forming (TS) glioma stem cells and cancerous TS cells were analyzed in vivo and in vitro. The boron concentration in murine TS tumors was higher than normal tissue. The boron concentration at 24 h was 0.80 ± 0.09 μg/107 in the TS cells, and 1.08 ± 0.08 μg/107 in the cancerous cells. The LAT-1 amino-acid transporter positive rate was 35.4% in the TS cells and 100% in the cancerous cells. These results suggested the relation between LAT-1 expression and boronophenylalanine concentration in vitro. •The boron (B) uptake of glioma stem cells (TS) and cancerous TS cells was analyzed.•1 h post-B treatment, TS tumor B conc. = 10 μg/g; that of normal brain = 7 μg/g.•The cancerous TS cells showed higher B conc. and LAT 1 expression than TS cells.