Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC
A novel magnetic organic porous polymer (denoted as Fe 3 O 4 @PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was charact...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2020-07, Vol.187 (7), p.388-388, Article 388 |
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| container_title | Mikrochimica acta (1966) |
| container_volume | 187 |
| creator | Li, Shanshan Zhang, Yintang Mu, Shuai Ma, Minrui Liu, Xiaoyan Zhang, Haixia |
| description | A novel magnetic organic porous polymer (denoted as Fe
3
O
4
@PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was characterized by scanning electron microscope, transmission electron microscope, FTIR, powder X-ray diffraction, and other techniques. The result of dynamic light scattering shows that the particle size of the adsorbent is mainly distributed around 400 nm. Based on the design concept of the Fe
3
O
4
@PC-POP, the proposed material can effectively capture the target analytes through electrostatic and hydrophobic interaction mechanism. Furthermore, the enrichment conditions were optimized by the response surface method, and the method was utilized for the determination of P-cresol and 4-hydroxybenzoic acid in real urine samples from health and gastric cancer patients with high enrichment factors (34.8 times for P-cresol and 38.7 times for 4-hydroxybenzoic acid), low limit of detection (0.9–5.0 μg L
−1
), wide linear ranges (3.0–1000 μg L
−1
), satisfactory relative standard deviation (2.5%–8.5%), and apparent recoveries (85.3–112% for healthy people’s and 86.0–112% for gastric cancer patients’ urine samples). This study provides a guided principle for design of the versatile polymer with specific capturing of the target compounds from complex biological samples.
Graphical abstract |
| doi_str_mv | 10.1007/s00604-020-04362-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2414009972</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A715056361</galeid><sourcerecordid>A715056361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-c4d03782b14c4222476d67039a19706996f97b4e955d5fb110b0695397c5a8f43</originalsourceid><addsrcrecordid>eNp9kt9u0zAUxiMEYmXwAlwgS9yMi4zjP7Gby6kaA6mIXbBry3Gc1iOxOzuR1j4dj7bTdjCBELKU49i_78vJ0VcUbymcUwD1MQNIECUwKEFwycrds2JGcVdWoPjzYgbAZMmlYifFq5xvAaiSTLwsTjirBBMSZsXPr2YV3OgtiWllAtZNTHHKWPrt4BIxmRiSY-_bcrM22RF3PyZjRx8DMW2OqXFhJF1MxIXk7XrYv5rQkrvJhNGP5kDGjqxMHhEg1gSLvo2Pg0k_XMrk7Lq0yeE3DjpRrrdtivdbNN5FFBjr2w_EBzIlHxzJZtj0LpNmS26ul4vXxYvO9Nm9eaynxc2ny--Lz-Xy29WXxcWytEKwEZ8tcDVnDRVWMMaEkq1UwGtDawWyrmVXq0a4uqraqmsohQZPK14rW5l5J_hpcXb03aR4N7k86sFn6_reBIfz0kxQAVDXiiH6_i_0Nk4pYHd7ildzQPSJWpneaR-6uJ_r3lRfKFpBJbmkSJ3_g8LVusHbGFzn8fwPATsKbIo5J9fpTfI46a2moPex0cfYaIyNPsRG71D07rHjqRlc-1vyKycI8COQ8SqsXHr6pf_YPgCiH83u</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2413580140</pqid></control><display><type>article</type><title>Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Li, Shanshan ; Zhang, Yintang ; Mu, Shuai ; Ma, Minrui ; Liu, Xiaoyan ; Zhang, Haixia</creator><creatorcontrib>Li, Shanshan ; Zhang, Yintang ; Mu, Shuai ; Ma, Minrui ; Liu, Xiaoyan ; Zhang, Haixia</creatorcontrib><description>A novel magnetic organic porous polymer (denoted as Fe
3
O
4
@PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was characterized by scanning electron microscope, transmission electron microscope, FTIR, powder X-ray diffraction, and other techniques. The result of dynamic light scattering shows that the particle size of the adsorbent is mainly distributed around 400 nm. Based on the design concept of the Fe
3
O
4
@PC-POP, the proposed material can effectively capture the target analytes through electrostatic and hydrophobic interaction mechanism. Furthermore, the enrichment conditions were optimized by the response surface method, and the method was utilized for the determination of P-cresol and 4-hydroxybenzoic acid in real urine samples from health and gastric cancer patients with high enrichment factors (34.8 times for P-cresol and 38.7 times for 4-hydroxybenzoic acid), low limit of detection (0.9–5.0 μg L
−1
), wide linear ranges (3.0–1000 μg L
−1
), satisfactory relative standard deviation (2.5%–8.5%), and apparent recoveries (85.3–112% for healthy people’s and 86.0–112% for gastric cancer patients’ urine samples). This study provides a guided principle for design of the versatile polymer with specific capturing of the target compounds from complex biological samples.
Graphical abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-020-04362-z</identifier><identifier>PMID: 32542460</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Acids ; Adsorbents ; Adsorption ; Amino acids ; Analysis ; Analytical Chemistry ; Biological markers ; Biological properties ; Biomarkers ; Biomarkers, Tumor - chemistry ; Biomarkers, Tumor - isolation & purification ; Biomarkers, Tumor - urine ; Cancer ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Chromatography, High Pressure Liquid ; Cresols - chemistry ; Cresols - isolation & purification ; Cresols - urine ; Diffraction ; Enrichment ; Gastric cancer ; Humans ; Hydrophobicity ; Iron oxides ; Limit of Detection ; Magnetite Nanoparticles - chemistry ; Microengineering ; Nanochemistry ; Nanotechnology ; Original Paper ; Parabens - analysis ; Parabens - chemistry ; Parabens - isolation & purification ; Particle size distribution ; Photon correlation spectroscopy ; Piperazines - chemistry ; Polymer industry ; Polymers ; Polymers - chemistry ; Porosity ; Response surface methodology ; Solid Phase Extraction - methods ; Solid phases ; Stomach cancer ; Stomach Neoplasms - urine ; Transmission electron microscopes ; Urine ; X ray powder diffraction ; X-rays</subject><ispartof>Mikrochimica acta (1966), 2020-07, Vol.187 (7), p.388-388, Article 388</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-c4d03782b14c4222476d67039a19706996f97b4e955d5fb110b0695397c5a8f43</citedby><cites>FETCH-LOGICAL-c442t-c4d03782b14c4222476d67039a19706996f97b4e955d5fb110b0695397c5a8f43</cites><orcidid>0000-0001-8789-5211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-020-04362-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-020-04362-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32542460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Zhang, Yintang</creatorcontrib><creatorcontrib>Mu, Shuai</creatorcontrib><creatorcontrib>Ma, Minrui</creatorcontrib><creatorcontrib>Liu, Xiaoyan</creatorcontrib><creatorcontrib>Zhang, Haixia</creatorcontrib><title>Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>A novel magnetic organic porous polymer (denoted as Fe
3
O
4
@PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was characterized by scanning electron microscope, transmission electron microscope, FTIR, powder X-ray diffraction, and other techniques. The result of dynamic light scattering shows that the particle size of the adsorbent is mainly distributed around 400 nm. Based on the design concept of the Fe
3
O
4
@PC-POP, the proposed material can effectively capture the target analytes through electrostatic and hydrophobic interaction mechanism. Furthermore, the enrichment conditions were optimized by the response surface method, and the method was utilized for the determination of P-cresol and 4-hydroxybenzoic acid in real urine samples from health and gastric cancer patients with high enrichment factors (34.8 times for P-cresol and 38.7 times for 4-hydroxybenzoic acid), low limit of detection (0.9–5.0 μg L
−1
), wide linear ranges (3.0–1000 μg L
−1
), satisfactory relative standard deviation (2.5%–8.5%), and apparent recoveries (85.3–112% for healthy people’s and 86.0–112% for gastric cancer patients’ urine samples). This study provides a guided principle for design of the versatile polymer with specific capturing of the target compounds from complex biological samples.
Graphical abstract</description><subject>Acids</subject><subject>Adsorbents</subject><subject>Adsorption</subject><subject>Amino acids</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Biological markers</subject><subject>Biological properties</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - chemistry</subject><subject>Biomarkers, Tumor - isolation & purification</subject><subject>Biomarkers, Tumor - urine</subject><subject>Cancer</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cresols - chemistry</subject><subject>Cresols - isolation & purification</subject><subject>Cresols - urine</subject><subject>Diffraction</subject><subject>Enrichment</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Hydrophobicity</subject><subject>Iron oxides</subject><subject>Limit of Detection</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Microengineering</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Parabens - analysis</subject><subject>Parabens - chemistry</subject><subject>Parabens - isolation & purification</subject><subject>Particle size distribution</subject><subject>Photon correlation spectroscopy</subject><subject>Piperazines - chemistry</subject><subject>Polymer industry</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>Response surface methodology</subject><subject>Solid Phase Extraction - methods</subject><subject>Solid phases</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - urine</subject><subject>Transmission electron microscopes</subject><subject>Urine</subject><subject>X ray powder diffraction</subject><subject>X-rays</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt9u0zAUxiMEYmXwAlwgS9yMi4zjP7Gby6kaA6mIXbBry3Gc1iOxOzuR1j4dj7bTdjCBELKU49i_78vJ0VcUbymcUwD1MQNIECUwKEFwycrds2JGcVdWoPjzYgbAZMmlYifFq5xvAaiSTLwsTjirBBMSZsXPr2YV3OgtiWllAtZNTHHKWPrt4BIxmRiSY-_bcrM22RF3PyZjRx8DMW2OqXFhJF1MxIXk7XrYv5rQkrvJhNGP5kDGjqxMHhEg1gSLvo2Pg0k_XMrk7Lq0yeE3DjpRrrdtivdbNN5FFBjr2w_EBzIlHxzJZtj0LpNmS26ul4vXxYvO9Nm9eaynxc2ny--Lz-Xy29WXxcWytEKwEZ8tcDVnDRVWMMaEkq1UwGtDawWyrmVXq0a4uqraqmsohQZPK14rW5l5J_hpcXb03aR4N7k86sFn6_reBIfz0kxQAVDXiiH6_i_0Nk4pYHd7ildzQPSJWpneaR-6uJ_r3lRfKFpBJbmkSJ3_g8LVusHbGFzn8fwPATsKbIo5J9fpTfI46a2moPex0cfYaIyNPsRG71D07rHjqRlc-1vyKycI8COQ8SqsXHr6pf_YPgCiH83u</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Li, Shanshan</creator><creator>Zhang, Yintang</creator><creator>Mu, Shuai</creator><creator>Ma, Minrui</creator><creator>Liu, Xiaoyan</creator><creator>Zhang, Haixia</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8789-5211</orcidid></search><sort><creationdate>20200701</creationdate><title>Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC</title><author>Li, Shanshan ; Zhang, Yintang ; Mu, Shuai ; Ma, Minrui ; Liu, Xiaoyan ; Zhang, Haixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c4d03782b14c4222476d67039a19706996f97b4e955d5fb110b0695397c5a8f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Adsorbents</topic><topic>Adsorption</topic><topic>Amino acids</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Biological markers</topic><topic>Biological properties</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - chemistry</topic><topic>Biomarkers, Tumor - isolation & purification</topic><topic>Biomarkers, Tumor - urine</topic><topic>Cancer</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cresols - chemistry</topic><topic>Cresols - isolation & purification</topic><topic>Cresols - urine</topic><topic>Diffraction</topic><topic>Enrichment</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Hydrophobicity</topic><topic>Iron oxides</topic><topic>Limit of Detection</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Microengineering</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Parabens - analysis</topic><topic>Parabens - chemistry</topic><topic>Parabens - isolation & purification</topic><topic>Particle size distribution</topic><topic>Photon correlation spectroscopy</topic><topic>Piperazines - chemistry</topic><topic>Polymer industry</topic><topic>Polymers</topic><topic>Polymers - chemistry</topic><topic>Porosity</topic><topic>Response surface methodology</topic><topic>Solid Phase Extraction - methods</topic><topic>Solid phases</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - urine</topic><topic>Transmission electron microscopes</topic><topic>Urine</topic><topic>X ray powder diffraction</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Zhang, Yintang</creatorcontrib><creatorcontrib>Mu, Shuai</creatorcontrib><creatorcontrib>Ma, Minrui</creatorcontrib><creatorcontrib>Liu, Xiaoyan</creatorcontrib><creatorcontrib>Zhang, Haixia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shanshan</au><au>Zhang, Yintang</au><au>Mu, Shuai</au><au>Ma, Minrui</au><au>Liu, Xiaoyan</au><au>Zhang, Haixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>187</volume><issue>7</issue><spage>388</spage><epage>388</epage><pages>388-388</pages><artnum>388</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>A novel magnetic organic porous polymer (denoted as Fe
3
O
4
@PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was characterized by scanning electron microscope, transmission electron microscope, FTIR, powder X-ray diffraction, and other techniques. The result of dynamic light scattering shows that the particle size of the adsorbent is mainly distributed around 400 nm. Based on the design concept of the Fe
3
O
4
@PC-POP, the proposed material can effectively capture the target analytes through electrostatic and hydrophobic interaction mechanism. Furthermore, the enrichment conditions were optimized by the response surface method, and the method was utilized for the determination of P-cresol and 4-hydroxybenzoic acid in real urine samples from health and gastric cancer patients with high enrichment factors (34.8 times for P-cresol and 38.7 times for 4-hydroxybenzoic acid), low limit of detection (0.9–5.0 μg L
−1
), wide linear ranges (3.0–1000 μg L
−1
), satisfactory relative standard deviation (2.5%–8.5%), and apparent recoveries (85.3–112% for healthy people’s and 86.0–112% for gastric cancer patients’ urine samples). This study provides a guided principle for design of the versatile polymer with specific capturing of the target compounds from complex biological samples.
Graphical abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>32542460</pmid><doi>10.1007/s00604-020-04362-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8789-5211</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-3672 |
| ispartof | Mikrochimica acta (1966), 2020-07, Vol.187 (7), p.388-388, Article 388 |
| issn | 0026-3672 1436-5073 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2414009972 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Acids Adsorbents Adsorption Amino acids Analysis Analytical Chemistry Biological markers Biological properties Biomarkers Biomarkers, Tumor - chemistry Biomarkers, Tumor - isolation & purification Biomarkers, Tumor - urine Cancer Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography Chromatography, High Pressure Liquid Cresols - chemistry Cresols - isolation & purification Cresols - urine Diffraction Enrichment Gastric cancer Humans Hydrophobicity Iron oxides Limit of Detection Magnetite Nanoparticles - chemistry Microengineering Nanochemistry Nanotechnology Original Paper Parabens - analysis Parabens - chemistry Parabens - isolation & purification Particle size distribution Photon correlation spectroscopy Piperazines - chemistry Polymer industry Polymers Polymers - chemistry Porosity Response surface methodology Solid Phase Extraction - methods Solid phases Stomach cancer Stomach Neoplasms - urine Transmission electron microscopes Urine X ray powder diffraction X-rays |
| title | Magnetic organic porous polymer as a solid-phase extraction adsorbent for enrichment and quantitation of gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) in urine samples by UPLC |
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